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1. (WO2006087644) MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/087644 International Application No.: PCT/IB2006/001238
Publication Date: 24.08.2006 International Filing Date: 13.01.2006
IPC:
C07H 17/00 (2006.01) ,C07H 17/08 (2006.01) ,A61K 31/7052 (2006.01) ,A61K 31/7048 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
08
Hetero rings containing eight or more ring members, e.g. erythromycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
CULIC, Ognjen [HR/HR]; HR (UsOnly)
BOSNAR, Martina [HR/HR]; HR (UsOnly)
MARJANOVIC, Nikola [HR/HR]; HR (UsOnly)
JELIC, Dubravko [HR/HR]; HR (UsOnly)
ALIHODZIC, Sulejman [HR/HR]; HR (UsOnly)
VELA, Vanja [HR/HR]; HR (UsOnly)
MARUSIC-ISTUK, Zorica [HR/HR]; HR (UsOnly)
ERAKOVIC, Vesna [HR/HR]; HR (UsOnly)
BOSNJAK, Berislav [HR/HR]; HR (UsOnly)
HRVACIC, Boska [HR/HR]; HR (UsOnly)
TOMASKOVIC, Marija [HR/HR]; HR (UsOnly)
MUNIC, Vesna [HR/HR]; HR (UsOnly)
IVETIC, Vanesa [HR/HR]; HR (UsOnly)
HUTINEC, Antun [HR/HR]; HR (UsOnly)
KRAGOL, Goran [HR/HR]; HR (UsOnly)
LELJAK, Marija [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 10000 Zagreb, HR (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
Inventors:
CULIC, Ognjen; HR
BOSNAR, Martina; HR
MARJANOVIC, Nikola; HR
JELIC, Dubravko; HR
ALIHODZIC, Sulejman; HR
VELA, Vanja; HR
MARUSIC-ISTUK, Zorica; HR
ERAKOVIC, Vesna; HR
BOSNJAK, Berislav; HR
HRVACIC, Boska; HR
TOMASKOVIC, Marija; HR
MUNIC, Vesna; HR
IVETIC, Vanesa; HR
HUTINEC, Antun; HR
KRAGOL, Goran; HR
LELJAK, Marija; HR
Priority Data:
60/643,84113.01.2005US
60/715,82809.09.2005US
Title (EN) MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
(FR) MACROLIDES PRESENTANT UNE ACTIVITE ANTI-INFLAMMATOIRE
Abstract:
(EN) The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4' position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-&agr;, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
(FR) L'invention concerne de nouveaux macrolides semi-synthétiques qui présentent une activité anti-inflammatoire. D'une manière plus spécifique, l'invention concerne des macrolides à 14 ou 15 éléments substitués en position 4', leurs dérivés pharmaceutiquement acceptables, des processus et des intermédiaires pour leur préparation, des compositions pharmaceutiques contenant ces macrolides ainsi que leur activité et leur utilisation dans le traitement de maladies et d'états inflammatoires sur des humains et des animaux, notamment des maladies associées à une sécrétion excessive de TNF-a, IL-1, IL-8, IL-2 ou IL-5 ; et/ou à l'inhibition d'une prolifération lymphocytaire excessive ; et/ou à une dégranulation excessive des granulocytes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)