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1. (WO2006087355) 1H-IMIDIAZOLE DERIVATIVES AS CANNABINOID CB2 RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/087355    International Application No.:    PCT/EP2006/060009
Publication Date: 24.08.2006 International Filing Date: 16.02.2006
Chapter 2 Demand Filed:    06.09.2006    
IPC:
C07D 233/90 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), A61K 31/4164 (2006.01), C07D 401/06 (2006.01), A61P 37/00 (2006.01), C07D 405/04 (2006.01), A61P 29/00 (2006.01), C07D 405/12 (2006.01), C07D 417/04 (2006.01), C07D 405/06 (2006.01)
Applicants: SOLVAY PHARMACEUTICALS B.V. [NL/NL]; C.J. Van Houtenlaan 36, NL-1381 CP Weesp (NL) (For All Designated States Except US).
LANGE, Josephus, H., M. [NL/NL]; (NL) (For US Only).
STUIVENBERG, Herman, H. [NL/NL]; (NL) (For US Only).
VAN VLIET, Bernard, J. [NL/NL]; (NL) (For US Only)
Inventors: LANGE, Josephus, H., M.; (NL).
STUIVENBERG, Herman, H.; (NL).
VAN VLIET, Bernard, J.; (NL)
Agent: VERHAGE, Marinus; Octrooibureau Zoan B.V., C.J. Van Houtenlaan 36, NL-1381 CP Weesp (NL)
Priority Data:
60/653,091 16.02.2005 US
05101171.6 16.02.2005 EP
Title (EN) 1H-IMIDIAZOLE DERIVATIVES AS CANNABINOID CB2 RECEPTOR MODULATORS
(FR) DERIVES DE 1H-IMIDIAZOLE EN TANT QUE MODULATEURS DES RECEPTEURS CANNABINOIDES CB2
Abstract: front page image
(EN)The invention relates to a group of 1 H-imidazole derivatives which are modulators of cannabinoid CB2 receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1 H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which cannabinoid CB2 receptors are involved. The compounds have the general formula (I) wherein R1-R4 have the meanings given in the specification.
(FR)L'invention concerne un groupe de dérivés de 1 H-imidazole qui sont des modulateurs de récepteurs cannabinoïdes CB2, des procédés pour la préparation de ces composés, de nouveaux intermédiaires utiles pour la synthèse desdits dérivés de l’imidazole, des procédés pour la préparation de ces intermédiaires, des compositions pharmaceutiques contenant une ou plusieurs de ces dérivés de 1 H-imidazole en tant que principe actif, ainsi que l’utilisation de ces compositions pharmaceutiques pour le traitement de troubles dans lesquels sont impliqués des récepteurs cannabinoïdes CB2. Les composés ont la formule générale (I) dans laquelle R1 à R4 ont les significations indiquées dans la description.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)