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1. (WO2006087306) DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/087306    International Application No.:    PCT/EP2006/050874
Publication Date: 24.08.2006 International Filing Date: 13.02.2006
IPC:
C07D 487/08 (2006.01), C07D 471/08 (2006.01), A61K 31/551 (2006.01), A61P 25/28 (2006.01)
Applicants: NEUROSEARCH A/S [DK/DK]; 93 Pederstrupvej, DK-2750 Ballerup (DK) (For All Designated States Except US).
PETERS, Dan [SE/DK]; (DK) (For US Only).
TIMMERMANN, Daniel, B. [DK/DK]; (DK) (For US Only).
OLSEN, Gunnar, M. [DK/DK]; (DK) (For US Only).
NIELSEN, Elsebet, Østergaard [DK/DK]; (DK) (For US Only).
DYHRING, Tino [DK/DK]; (DK) (For US Only)
Inventors: PETERS, Dan; (DK).
TIMMERMANN, Daniel, B.; (DK).
OLSEN, Gunnar, M.; (DK).
NIELSEN, Elsebet, Østergaard; (DK).
DYHRING, Tino; (DK)
Common
Representative:
NEUROSEARCH A/S; Patent Department, 93 Pederstrupvej, DK-2750 Ballerup (DK)
Priority Data:
PA 2005 00230 16.02.2005 DK
60/653,491 17.02.2005 US
PA 2005 01723 06.12.2005 DK
Title (EN) DIAZABICYCLIC ARYL DERIVATIVES AND THEIR USE AS CHOLINERGIC LIGANDS AT THE NICOTINIC ACETYLCHOLINE RECEPTORS
(FR) NOUVEAUX DERIVES ARYLE DIAZABICYCLIQUES ET LEUR UTILISATION MEDICALE
Abstract: front page image
(EN)This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
(FR)L'invention concerne de nouveaux dérivés aryle diazabicycliques dont on a découvert qu'ils étaient des ligands cholinergiques au niveau des récepteurs nicotiniques de l'acétylcholine et des modulateurs des récepteurs et des transporteurs de la monoamine. Du fait de leur profil pharmacologique, les composés selon l'invention peuvent être utilisés pour traiter des maladies et des troubles aussi divers que ceux associés au système cholinergique du système nerveux central (SNC) et du système nerveux périphérique (SNP), des maladies ou des troubles associés à la contraction des muscles lisses, des maladies ou des troubles endocriniens, des maladies ou des troubles associés à la neurodégénérescence et des maladies ou des troubles associés aux inflammations, aux douleurs et aux symptômes de sevrage entraînés par l'arrêt de la consommation du substances chimiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)