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1. (WO2006087229) SUBSTITUTED PYRIDO (2 , 3-D) PYRIMIDINE DERIVATIVES USEFUL AS MEDICINES FOR THE TREATMENT OF AUTOIMMUNE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/087229    International Application No.:    PCT/EP2006/001539
Publication Date: 24.08.2006 International Filing Date: 21.02.2006
Chapter 2 Demand Filed:    20.12.2006    
IPC:
C07D 471/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: 4 AZA IP NV [BE/BE]; Kapucijnenvoer 33, B-3000 Leuven (BE) (For All Designated States Except US).
DE JONGHE, Steven, Cesar, Alfons [BE/BE]; (BE) (For US Only).
HERDEWIJN, Piet, André, Maurits, Maria [BE/BE]; (BE) (For US Only).
GAO, Ling-Jie [CN/BE]; (BE) (For US Only)
Inventors: DE JONGHE, Steven, Cesar, Alfons; (BE).
HERDEWIJN, Piet, André, Maurits, Maria; (BE).
GAO, Ling-Jie; (BE)
Agent: BIRD, William, E.; Bird Goën & Co., Klein Dalenstraat 42A, B-3020 Winksele (BE)
Priority Data:
0503506.8 21.02.2005 GB
Title (EN) SUBSTITUTED PYRIDO (2 , 3-D) PYRIMIDINE DERIVATIVES USEFUL AS MEDICINES FOR THE TREATMENT OF AUTOIMMUNE DISORDERS
(FR) DERIVES SUBSTITUES DE PYRIDO (2 , 3-D) PYRIMIDINE UTILES EN TANT QUE MEDICAMENTS POUR LE TRAITEMENT DES TROUBLES AUTOIMMUNS
Abstract: front page image
(EN)This invention relates to a group of trisubstituted pyrido(2,3-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-&agr; related disorders and cell proliferative disorders.
(FR)La présente invention concerne un groupe de dérivés trisubstitués de pyrido(2,3-d)pyrimidine, leurs sels pharmaceutiquement acceptables, des/leurs oxydes N, des solvates et énantiomères possédant des propriétés pharmaceutiques souhaitables inattendues, notamment en tant qu’agents immunosuppresseurs extrêmement actifs, et étant à ce titre utiles dans le traitement du rejet de greffe et/ou dans le traitement de certaines maladies inflammatoires. Ces dérivés sont également utiles dans la prévention ou le traitement des troubles cardiovasculaires, des troubles du système nerveux central, des troubles liées au TNF-&agr; et des troubles associés à la prolifération cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)