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1. (WO2006086737) MIR-155 ASSAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/086737    International Application No.:    PCT/US2006/004945
Publication Date: 17.08.2006 International Filing Date: 13.02.2006
IPC:
C12Q 1/68 (2006.01)
Applicants: WISCONSIN ALUMNI REASEARCH FOUNDATION [US/US]; P.O. Box 7365, Madison, WI 53707 (US) (For All Designated States Except US).
DAHLBERG, James, E. [US/US]; (US) (For US Only).
EIS, Peggy, S. [US/US]; (US) (For US Only).
TAM, Wayne [US/US]; (US) (For US Only).
LUND, Elsebet [US/US]; (US) (For US Only).
CORNELL RESEARCH FOUNDATION, INC. [US/US]; 395 Pine Tree Road, Suite 310, Ithaca, NY 14850 (US) (For All Designated States Except US)
Inventors: DAHLBERG, James, E.; (US).
EIS, Peggy, S.; (US).
TAM, Wayne; (US).
LUND, Elsebet; (US)
Agent: ZUHN, Donald, L., Jr.; McDONNELL BOEHNEN HULBERT & BERGHOFF LLP, 300 South Wacker Drive, Suite 3100, Chicago, IL 60606 (US)
Priority Data:
60/652,301 11.02.2005 US
60/656,245 25.02.2005 US
Title (EN) MIR-155 ASSAY
(FR) ESSAI MIR-155
Abstract: front page image
(EN)The invention provides methods for diagnosing B-cell lymphoma in an animal. In particular, the invention provides methods for distinguishing an animal having diffuse large B-cell lymphoma (DLBCL) with an activated B-cell (ABC) phenotype from an animal having DLBCL with a non-activated germinal-center (GC) phenotype. The invention also provides methods for identifying compounds for treating B-cell lymphoma. The invention further provides reagents and methods for determining the amount of miR-155 in sample isolated from an animal. In this regard, the invention provides a set of oligonucleotides for determining the amount of miR-155 in sample isolated from an animal.
(FR)L'invention concerne des méthodes de diagnostic du lymphome B chez un animal, en particulier des méthodes permettant de distinguer un animal souffrant d'un lymphome B diffus à grandes cellules avec phénotype de cellules B acitvé d'un autre animal avec DLBCL et phénotype à centre germinatif non activé. L'invention concerne également des méthodes d'identification de composés utiles pour le traitement du lymphome B. Elle porte en outre sur des réactifs et des méthodes permettant de déterminer la quantité de miR-155 dans un échantillon prélevé sur un animal, ceci au moyen d'un ensemble d'oligonucléotides.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)