US2006004879 SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT<sub>2A</sub> ANTAGONISTS

1. (WO2006086705) SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT_2A ANTAGONISTS

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Latest bibliographic data on file with the International Bureau

Pub. No.:	WO/2006/086705	International Application No.:	PCT/US2006/004879
Publication Date:	17.08.2006	International Filing Date:	10.02.2006
Chapter 2 Demand Filed:	08.11.2006

IPC:

C07D 209/08 (2006.01), C07D 277/68 (2006.01), C07D 263/58 (2006.01), C07D 239/96 (2006.01), C07D 235/26 (2006.01), C07D 231/56 (2006.01), C07D 265/34 (2006.01), C07D 249/18 (2006.01), C07D 401/14 (2006.01), C07D 413/14 (2006.01), C07D 471/04 (2006.01), C07D 405/04 (2006.01), C07D 413/12 (2006.01), C07D 409/14 (2006.01), C07D 409/04 (2006.01)

Applicants:

AVENTIS PHARMACEUTICALS INC. [US/US]; 300 Somerset Corporate Boulevard, Bridgewater, New Jersey 08807-2854 (US) (For All Designated States Except US).
FINK, David Mark [US/US]; (US) (For US Only).
SMITH, Helen Katherine [GB/GB]; (GB) (For US Only).
TODD, Richard Simon [GB/GB]; (GB) (For US Only).
EASTWOOD, Paul Robert [GB/ES]; (ES) (For US Only).
HUNT, Hazel [GB/GB]; (GB) (For US Only)

Inventors:

FINK, David Mark; (US).
SMITH, Helen Katherine; (GB).
TODD, Richard Simon; (GB).
EASTWOOD, Paul Robert; (ES).
HUNT, Hazel; (GB)

Agent:

GUPTA, Balaram; Sanofi-Aventis, Route 202-206, P. O. Box 6800, Bridgewater, NJ 08807-0800 (US)

Priority Data:

60/651,911

10.02.2005

Title

(EN) SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT_2A ANTAGONISTS
(FR) COMPOSES BIS ARYLE ET HETEROARYLE SUBSTITUES, UTILES COMME ANTAGONISTES SELECTIFS DES RECEPTEURS 5HT_2A

Abstract:

(EN)The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R₁ and R₂ are as defined herein. The compounds of this invention are selective 5HT_2A antagonists, and are therefore, useful in treating a variety of diseases including but not limited to a wide variety of sleep disorders as disclosed and claimed herein.
(FR)La présente invention concerne une série de composés bis aryle et hétéroaryle substitués, représentés par la formule générale (I). Dans cette formule, X, Y, Z, A, B, D, Ar, R₁ et R₂ désignent des éléments définis dans la partie descriptive de la présente demande. Les composés de la présente invention sont des antagonistes sélectifs des récepteurs 5HT_2A et sont, par conséquent, utiles pour le traitement de diverses maladies, notamment, mais sans en exclure d'autres, un grand nombre de troubles du sommeil.

Designated States:

AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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