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Machine translation
1. (WO2006086600) PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/086600    International Application No.:    PCT/US2006/004664
Publication Date: 17.08.2006 International Filing Date: 10.02.2006
IPC:
C07F 5/02 (2006.01), A61K 31/69 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01)
Applicants: CEPHALON, INC. [US/US]; 41 Mores Road, Frazer, Pennsylvania 19355 (US) (For All Designated States Except US).
OLIVA, Ambrogio [IT/IT]; (IT) (For US Only).
BERNARDNINI, Raffaella [IT/IT]; (IT) (For US Only).
D'ARASMO, Germano [IT/IT]; (IT) (For US Only).
CASSARA, Paolo, G. [IT/IT]; (IT) (For US Only).
BERNAREGGI, Alberto [IT/IT]; (IT) (For US Only).
MENTA, Ernesto [IT/IT]; (IT) (For US Only)
Inventors: OLIVA, Ambrogio; (IT).
BERNARDNINI, Raffaella; (IT).
D'ARASMO, Germano; (IT).
CASSARA, Paolo, G.; (IT).
BERNAREGGI, Alberto; (IT).
MENTA, Ernesto; (IT)
Agent: WOODCOCK WASHBURN LLP; 2929 Arch Street - Suite 1200, Philadelphia, PA 19104-2891 (US)
Priority Data:
60/652,370 11.02.2005 US
11/351,193 09.02.2006 US
Title (EN) PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
(FR) INHIBITEURS DU PROTEASOME ET LEURS METHODES D'UTILISATION
Abstract: front page image
(EN)The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.
(FR)La présente invention concerne des composés d'acide boronique, des esters boroniques et des compositions associées qui permettent de moduler l'apoptose, comme par inhibition de l'activité du protéasome. Les composés et les compositions peuvent être utilisés dans des méthodes d'induction de l'apoptose et de traitement de maladies, telles que le cancer et d'autres troubles directement ou indirectement liés à l'activité du protéasome.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)