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Machine translation
1. (WO2006086288) METHODS FOR REDUCING THE SYMPTOMS OF AUTOIMMUNITY AND INFLAMMATION USING BINDING PROTEINS AGAINST ANTIGENS EXPOSED ON DEAD OR DYING CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/086288    International Application No.:    PCT/US2006/004065
Publication Date: 17.08.2006 International Filing Date: 07.02.2006
IPC:
A61K 39/00 (2006.01), A61K 39/395 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; Office of the President, 1111 Franklin Street, 5th Floor, Oakland, California 94607-5200 (US) (For All Designated States Except US).
SILVERMAN, Gregg, J. [US/US]; (US) (For US Only)
Inventors: SILVERMAN, Gregg, J.; (US)
Agent: ADRIANO, Sarah; Mandel & Adriano, 55 South Lake Avenue, Suite 710, Pasadena, California 91101 (US)
Priority Data:
60/650,458 07.02.2005 US
Title (EN) METHODS FOR REDUCING THE SYMPTOMS OF AUTOIMMUNITY AND INFLAMMATION USING BINDING PROTEINS AGAINST ANTIGENS EXPOSED ON DEAD OR DYING CELLS
(FR) METHODES POUR REDUIRE LES SYMPTOMES D'AUTO-IMMUNITE ET D'INFLAMMATION AU MOYEN DE PROTEINES DE LIAISON DIRIGEES CONTRE DES ANTIGENES EXPOSES SUR DES CELLULES MORTES OU MOURANTES
Abstract: front page image
(EN)The present invention relates to a method for inhibiting a disease response in a subject comprising contacting dead or dying cells exposing an antigen selected from the group consisting of a phosphorylcholine (PC) determinant, a phosphatidyl serine (PS) determinant, a MDA determinant, and cardiolipin in the subject, with an antibody or recombinant protein that recognizes and binds the antigen that is exposed on the dead or dying cells, thereby inhibiting the pathologic response in the subject.
(FR)L'invention concerne une méthode pour inhiber une réponse pathologique chez un sujet. Cette méthode consiste à mettre en contact des cellules mortes ou mourantes exposant un antigène sélectionné dans le groupe comprenant un déterminant de phosphorylcholine (PC), un déterminant de phosphatidyl sérine (PS), un déterminant de MDA, une cardiolipine, chez le patient, avec un anticorps ou une protéine recombinante reconnaissant et se liant à l'antigène qui est exposé sur les cellules mortes ou mourantes, ce qui permet d'inhiber la réponse pathologique chez ce patient.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)