WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006086255) INHIBITORS OF CHECKPOINT KINASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/086255    International Application No.:    PCT/US2006/003981
Publication Date: 17.08.2006 International Filing Date: 03.02.2006
IPC:
C07D 235/06 (2006.01), A61K 31/4184 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
ARRINGTON, Kenneth, L. [US/US]; (US) (For US Only).
FRALEY, Mark, E. [US/US]; (US) (For US Only).
GARBACCIO, Robert, M. [US/US]; (US) (For US Only).
HUANG, Shaei, Y. [CN/US]; (US) (For US Only).
LINDSLEY, Craig, W. [US/US]; (US) (For US Only).
STEEN, Justin, T. [US/US]; (US) (For US Only).
YANG, Feng [CN/US]; (US) (For US Only)
Inventors: ARRINGTON, Kenneth, L.; (US).
FRALEY, Mark, E.; (US).
GARBACCIO, Robert, M.; (US).
HUANG, Shaei, Y.; (US).
LINDSLEY, Craig, W.; (US).
STEEN, Justin, T.; (US).
YANG, Feng; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/651,110 08.02.2005 US
Title (EN) INHIBITORS OF CHECKPOINT KINASES
(FR) INHIBITEURS DE KINASES DE CONTROLE
Abstract: front page image
(EN)The instant invention provides for compounds which comprise substituted indolyl indazoles that inhibit CHK1 activity. The instant compounds provide a novel mechanism of action with unexpected advantageous properties; such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
(FR)L'invention se rapporte à des composés contenant des indazoles d'indolyl substitués qui inhibent l'activité de CHK1. Ces composés fournissent un nouveau mécanisme d'action présentant des propriétés avantageuses inédites ; ces propriétés avantageuses inédites comprenant une meilleure puissance/solubilité cellulaire, une meilleure sélectivité, des propriétés pharmacocinétiques améliorées, un manque d'activité hors cible etc. Cette invention se rapporte aussi à des compositions contenant ces composés inhibiteurs et à des procédés d'inhibition de l'activité de CHK1 par administration du composé à un patient qui doit recevoir un traitement contre le cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)