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1. (WO2006086108) USE OF INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO SYNERGIZE ACTIVITY OF COX AND 5-LOX INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/086108    International Application No.:    PCT/US2006/000914
Publication Date: 17.08.2006 International Filing Date: 10.01.2006
IPC:
A61K 31/42 (2006.01), A61K 31/415 (2006.01)
Applicants: REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; Office of Technology Transfer, 1111 Franklin Street, 5th Floor, Oakland, California 94607 (US) (For All Designated States Except US).
HAMMOCK, Bruce D. [US/US]; (US) (For US Only).
SCHMELZER, Kara [US/US]; (US) (For US Only).
INCEOGLU, Ahmet Bora [TR/US]; (US) (For US Only)
Inventors: HAMMOCK, Bruce D.; (US).
SCHMELZER, Kara; (US).
INCEOGLU, Ahmet Bora; (US)
Agent: HYMAN, Laurence J.; TOWNSEND AND TOWNSEND AND CREW, LLP, 2 Embarcadero Center, Eighth Floor, San Francisco, California 94111-3834 (US)
Priority Data:
60/643,028 10.01.2005 US
Title (EN) USE OF INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO SYNERGIZE ACTIVITY OF COX AND 5-LOX INHIBITORS
(FR) UTILISATION D'INHIBITEURS DE L'EPOXYDE HYDROLASE SOLUBLE POUR SYNERGISER L'ACTIVITE D'INHIBITEURS DE COX ET DE 5-LOX
Abstract: front page image
(EN)The invention relates to methods, compositions , and uses of those compositions for making medicaments, for potentiating the beneficial effects of inhibitors of COX-1, COX-2, and 5-LOX, and reducing adverse effects, by also administering inhibitors of soluble epoxide hydrolase ('sEH'), with or without also administering one or more cis-epoxyeicosantrienoic acids. The invention further relates to the use of inhibitors of sEH as analgesics and to methods and compositions of epoxides of eicosapentaenoic acid and docosahexaenoic acid to reduce pain or inflammation or both.
(FR)L'invention concerne des méthodes, des compositions et des utilisations de ces compositions pour fabriquer des médicaments destinés à potentialiser les effets bénéfiques d'inhibiteurs de COX-1, de COX-2 et de 5-LOX ainsi qu'à réduire les effets indésirables, également par administration d'inhibiteurs de l'époxyde hydrolase soluble (sEH) avec ou sans administration concomitante d'un ou plusieurs acides cis-époxyeicosatriénoïques. L'invention concerne également l'utilisation d'inhibiteurs de sEH comme analgésiques ainsi que des méthodes et des compositions d'époxydes d'acide eicosapentaénoïque et d'acide docosahexaénoïque destinées à réduire la douleur et/ou l'inflammation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)