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Machine translation
1. (WO2006085747) CONTROLLED RELEASE COMPOSITIONS FOR INTERFERON BASED ON PEGT/PBT BLOCK COPOLYMERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/085747    International Application No.:    PCT/NL2006/000006
Publication Date: 17.08.2006 International Filing Date: 06.01.2006
IPC:
A61K 9/113 (2006.01), A61K 9/16 (2006.01), A61K 9/19 (2006.01), A61K 47/34 (2006.01), A61K 38/21 (2006.01), A61P 31/12 (2006.01), A61P 31/18 (2006.01)
Applicants: OCTOPLUS SCIENCES B.V. [NL/NL]; Zernikedreef 12, NL-2333 CL Leiden (NL) (For All Designated States Except US).
BECHET, Anne, Chantal [FR/NL]; (NL) (For US Only).
VAN DIJKHUIZEN-RADERSMA, Riemke [NL/NL]; (NL) (For US Only).
STIGTER, Martin [NL/NL]; (NL) (For US Only).
BEZEMER, Jeroen, Mattijs [NL/NL]; (NL) (For US Only)
Inventors: BECHET, Anne, Chantal; (NL).
VAN DIJKHUIZEN-RADERSMA, Riemke; (NL).
STIGTER, Martin; (NL).
BEZEMER, Jeroen, Mattijs; (NL)
Agent: WINCKELS, J.H.F.; C/o Vereenigde, Johan De Wittlaan 7, NL-2517 JR The Hague (NL)
Priority Data:
05075043.9 07.01.2005 EP
Title (EN) CONTROLLED RELEASE COMPOSITIONS FOR INTERFERON BASED ON PEGT/PBT BLOCK COPOLYMERS
(FR) PRÉPARATIONS À LIBÉRATION CONTRÔLÉE D'INTERFÉRONS BASÉES SUR DES COPOLYMÈRES BLOC PEGT/PBT
Abstract: front page image
(EN)The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an in-jectable liquid which may have self-gelling properties, or of a solid implant. The inven-tion further provides a pharmaceutical kit comprising the composition, methods for pre-paring the composition, and the pharmaceutical uses relating thereto.
(FR)La présente invention porte sur une préparation pharmaceutique permettant la libération contrôlée de composés actifs relativement toxiques, en particulier de protéines bioactives de la classe des interférons. La préparation comprend un copolymère bloc biodégradable construit à partir de poly(téréphtalate d’éthylène glycol) (PEGT) et de poly(téréphtalate de butylène) (PBT). La préparation se présente sous forme de microparticules injectables, d'une solution injectable qui peut être auto-gélifiante, ou d'un implant solide. La présente invention porte en outre sur un kit pharmaceutique comprenant la préparation, des méthodes d'élaboration de la préparation, et les applications pharmaceutiques correspondantes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)