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1. (WO2006085673) HAIRLESS TRANSGENIC ANIMAL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/085673    International Application No.:    PCT/JP2006/302590
Publication Date: 17.08.2006 International Filing Date: 08.02.2006
Chapter 2 Demand Filed:    08.12.2006    
IPC:
A01K 67/027 (2006.01), C12N 15/09 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01), C12N 5/10 (2006.01)
Applicants: TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH [JP/JP]; 8-1, Nishi-Shinjuku 2-chome Shinjuku-ku, Tokyo 1638001 (JP) (For All Designated States Except US).
NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY [JP/JP]; 8916-5, Takayama-cho Ikoma-shi, Nara 6300192 (JP) (For All Designated States Except US).
YONEKAWA, Hiromichi [JP/JP]; (JP) (For US Only).
TAKADA, Toyoyuki [JP/JP]; (JP) (For US Only).
SHITARA, Hiroshi [JP/JP]; (JP) (For US Only).
KIKKAWA, Yoshiaki [JP/JP]; (JP) (For US Only).
ISHII, Rie [JP/JP]; (JP) (For US Only).
KOHNO, Kenji [JP/JP]; (JP) (For US Only)
Inventors: YONEKAWA, Hiromichi; (JP).
TAKADA, Toyoyuki; (JP).
SHITARA, Hiroshi; (JP).
KIKKAWA, Yoshiaki; (JP).
ISHII, Rie; (JP).
KOHNO, Kenji; (JP)
Agent: KOBAYASHI, Hiroshi; c/o ABE, IKUBO & KATAYAMA Fukuoka Bldg., 9th Fl. 8-7, Yaesu 2-chome Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2005-032310 08.02.2005 JP
Title (EN) HAIRLESS TRANSGENIC ANIMAL
(FR) ANIMAL TRANSGENIQUE SANS POILS
(JA) 無毛トランスジェニック動物
Abstract: front page image
(EN)It is intended to provide a hairless transgenic nonhuman animal to be used in developing a therapy for dermatitis such as human atopic dermatitis and drug discovery. More specifically speaking, a transgenic nonhuman animal into which a recombinant DNA containing a heparin-binding EGF gene and a type 2 keratin gene promoter capable of regulating the expression of the above-described gene has been transferred.
(FR)La présente invention concerne un animal non humain transgénique sans poils, destiné à être utilisé pour le développement d'une thérapie pour les dermatites, telles que la dermatite atopique humaine, et la découverte de médicaments. L'invention concerne plus spécifiquement un animal transgénique non humain dans lequel on a transféré un ADN recombinant contenant un gène de l'EGF se liant à l'héparine et un promoteur du gène de la kératine de type 2 capable de réguler l'expression du gène décrit ci-dessus.
(JA)本発明は、ヒトアトピー性皮膚炎等の皮膚炎の治療法・創薬開発のための無毛トランスジェニック非ヒト動物の提供に関する。具体的には、本発明は、ヘパリン結合性EGF遺伝子及び前記遺伝子の発現を調節する2型ケラチン遺伝子プロモーターを含む組換え体DNAが導入された、トランスジェニック非ヒト動物の提供に関する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)