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1. (WO2006085612) METHOD FOR PREPARATION OF NEURAL STEM CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/085612    International Application No.:    PCT/JP2006/302350
Publication Date: 17.08.2006 International Filing Date: 10.02.2006
IPC:
C12N 5/02 (2006.01), C12N 5/06 (2006.01), A01K 67/027 (2006.01), A61K 35/28 (2006.01), A61K 35/30 (2006.01), A61L 27/00 (2006.01), A61P 9/10 (2006.01), A61P 25/00 (2006.01), C07K 14/52 (2006.01), C07K 14/54 (2006.01), C12Q 1/02 (2006.01)
Applicants: THE NEW INDUSTRY RESEARCH ORGANIZATION [JP/JP]; 1-5-2, Minatojima-minamimachi, Chuo-ku, Kobe-shi, Hyogo 6500047 (JP) (For All Designated States Except US).
JAPAN HEALTH SCIENCES FOUNDATION [JP/JP]; Kyodo Bldg., 13-4, Nihonbashi Kodenma-cho, Chuo-ku, Tokyo 1030001 (JP) (For All Designated States Except US).
MATSUYAMA, Tomohiro [JP/JP]; (JP) (For US Only).
TAGUCHI, Akihiko [JP/JP]; (JP) (For US Only).
YOSHIKAWA, Hiroo [JP/JP]; (JP) (For US Only)
Inventors: MATSUYAMA, Tomohiro; (JP).
TAGUCHI, Akihiko; (JP).
YOSHIKAWA, Hiroo; (JP)
Agent: TSUBURAYA, Toru; Room1616, Osaka Ekimae Dai-3 Bldg. 1-1-3, Umeda, Kita-ku Osaka-shi, Osaka 5300001 (JP)
Priority Data:
2005-035032 10.02.2005 JP
Title (EN) METHOD FOR PREPARATION OF NEURAL STEM CELLS
(FR) MÉTHODE DE PRÉPARATION DE CELLULES SOUCHES NEURALES
(JA) 神経幹細胞の調製法
Abstract: front page image
(EN)(1) A method for the preparation of neural stem cells comprising culturing marrow cells in the presence of an immunosuppressing agent or serum collected from a human or animal suffering from cerebral infarction (or, in place of the serum, a cytokine such as a chemokine); (2) a method for the preparation of neural stem cells comprising culturing marrow cells collected from a human or animal suffering from cerebral infarction in the presence of an immunosuppressing agent; and the like. These methods are useful for the nerve regenerative therapy or the development of such a therapy.
(FR)La présente invention a pour objet (1) une méthode de préparation de cellules souches neurales comprenant la culture de cellules de moelle osseuse en présence d'un agent immunosuppresseur ou de sérum collecté chez un humain ou un animal ayant subi un infarctus cérébral (ou, au lieu du sérum, une cytokine telle qu'une chimiokine) ; (2) une méthode de préparation de cellules souches neurales comprenant la culture de cellules de moelle osseuse collectées chez un humain ou un animal ayant subi un infarctus cérébral en présence d'un agent immunosuppresseur ; etc. Ces méthodes peuvent être employées dans une thérapie de régénération nerveuse ou pour le développement d'une telle thérapie.
(JA)本発明は、(1)免疫抑制剤、および、脳梗塞後のヒト又は動物から採取した血清(あるいは当該血清の代わりにケモカイン等のサイトカイン)を添加して骨髄細胞を培養することにより、神経幹細胞を調製する方法、(2)脳梗塞後のヒト又は動物から採取した骨髄細胞を、免疫抑制剤を添加して培養することにより、神経幹細胞を調製する方法、等を提供するものであり、神経再生治療又はその治療法開発に有用である。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)