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1. WO2006085228 - 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY

Publication Number WO/2006/085228
Publication Date 17.08.2006
International Application No. PCT/IB2006/001227
International Filing Date 13.01.2006
IPC
A61K 31/7052 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A61P 33/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06Antimalarials
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
CPC
A61K 31/7052
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A61P 33/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
A61P 33/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06Antimalarials
C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Y02A 50/30
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection, e.g. against extreme weather
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applicants
  • GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR]/[HR] (AllExceptUS)
  • BUKVIC KRAJACIC, Mirjana [HR]/[HR] (UsOnly)
  • KUJUNDZIC, Nedjeljko [HR]/[HR] (UsOnly)
  • IVEZIC, Zrinka [HR]/[HR] (UsOnly)
  • ALIHODZIC, Sulejman [HR]/[HR] (UsOnly)
  • HUTINEC, Antun [HR]/[HR] (UsOnly)
  • FAJDETIC, Andrea [HR]/[HR] (UsOnly)
Inventors
  • BUKVIC KRAJACIC, Mirjana
  • KUJUNDZIC, Nedjeljko
  • IVEZIC, Zrinka
  • ALIHODZIC, Sulejman
  • HUTINEC, Antun
  • FAJDETIC, Andrea
Priority Data
60/644,36014.01.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 9A-CARBAMOYL-Y-AMINOPROPYL AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY
(FR) NOUVEAUX AZALIDES 9A-CARBAMOYL-AMINOALKYLE ET 9A-THIOCARBAMOYLE-AMINOALKYLE ANTIPALUDEENS
Abstract
(EN) Novel 9a-N'-substituted-carbamoyl- and tMocarbamoyl-aminoalkyl-9a-aza-9-deoxo- 9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro- 9a-homoerythromycin A compounds having antimalarial activity are claimed. More particularly, the invention relates to 9a-N'-substituted-carbamoyl- and thiocarbamoyl- ß-aminoethyl- or -ϝ-aminopropyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
(FR) La présente invention concerne des nouveaux composés -N'-substitués-carbamoyl- et tMocarbamoyl-aminoalkyl-9a~aza-9-déoxo- 9-dihydro-9a-homoérythromycine A et 3~0-décladinosyl-9a-aza-9-déoxo-9-dihydro- 9a-homoérythromycine A possédant une activité antiplaludéenne. Cette invention concerne plus particulièrement des composés 9a-N'-substitués-carbamoyl- et thiocarbamoy- ß-aminoéthyl- ou -?-aminopropyl-9a-aza-9-déoxo-9-dihydro-9a-homoérythromycine A et 3-O-décladinosyl-9a-aza-9-déoxo-9-dihydro-9a-homoérythromycine A et des dérivés de ceux-ci répondant aux normes pharmaceutiques possédant une activité antipaludéenne.
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