WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006085212) CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/085212    International Application No.:    PCT/IB2006/000285
Publication Date: 17.08.2006 International Filing Date: 13.02.2006
IPC:
C07D 498/10 (2006.01), C07D 261/20 (2006.01), C07D 498/04 (2006.01), A61K 31/423 (2006.01), A61K 31/424 (2006.01), A61P 11/00 (2006.01), A61P 31/18 (2006.01)
Applicants: RANBAXY LABORATORIES LIMITED [IN/IN]; Plot No. 90, Sector - 32, Gurgaon, Haryana 122 001 (IN) (For All Designated States Except US).
PALLE, Venkata, P. [IN/IN]; (IN) (For US Only).
BALACHANDRAN, Sarala [IN/IN]; (IN) (For US Only).
GUPTA, Nidhi [IN/IN]; (IN) (For US Only).
MUTHUKAMAL, Nagarajan [IN/IN]; (IN) (For US Only).
RAMAIAH, Mandadapu, Raghu [IN/IN]; (IN) (For US Only).
KHERA, Manoj, Kumar [IN/IN]; (IN) (For US Only).
BAREGAMA, Lailt, Kumar [IN/IN]; (IN) (For US Only).
KAHIRNAR, Vinayak, Vasantrao [IN/IN]; (IN) (For US Only).
RAY, Abhijit [IN/IN]; (IN) (For US Only).
DASTIDAR, Sunanda, G. [IN/IN]; (IN) (For US Only)
Inventors: PALLE, Venkata, P.; (IN).
BALACHANDRAN, Sarala; (IN).
GUPTA, Nidhi; (IN).
MUTHUKAMAL, Nagarajan; (IN).
RAMAIAH, Mandadapu, Raghu; (IN).
KHERA, Manoj, Kumar; (IN).
BAREGAMA, Lailt, Kumar; (IN).
KAHIRNAR, Vinayak, Vasantrao; (IN).
RAY, Abhijit; (IN).
DASTIDAR, Sunanda, G.; (IN)
Common
Representative:
RANBAXY LABORATORIES LIMITED; c/o DESHMUKH, Jay R., 600 College Road East, Suite 2100, Princeton, NJ 08540 (US)
Priority Data:
303/DEL/2005 11.02.2005 IN
Title (EN) CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
(FR) INHIBITEURS DE LA PHOSPHODIESTERASE DE TYPE IV
Abstract: front page image
(EN)The present invention relates to isoxazoline derivatives of fprmula (I), which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
(FR)Cette invention concerne des dérivés isoxazoline, qui peuvent être utilisés comme inhibiteurs sélectifs de la phosphodiestérase (PDE) de type IV. Les composés de cette invention peuvent en particulier être utilisés pour traiter le SIDA, l'asthme, l'arthrite, la bronchite, la bronchopneumopathie chronique obstructive (BPCO), le psoriasis, la rhinite allergique, un choc, la dermatite atopique, la maladie de Crohn, le syndrome de détresse respiratoire aiguë de l'adulte (SDRA), le granulome à éosinophiles, la conjonctivite allergique, l'ostéoarthrite, la colite ulcéreuse et autres maladies inflammatoires chez un patient, en particulier chez des êtres humains. Cette invention concerne également des procédés de préparation des composés de cette invention, des compositions pharmaceutiques renfermant ces composés ainsi que leur utilisation comme inhibiteurs de la phosphodiestérase (PDE) de type IV.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)