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1. (WO2006085108) AWTHRANILIC ACID DERIVATIVES AND THEIR USE IN TREATMENT OF DISEASES OF LIPID METABOLISM, IN PARTICULAR DYSLIPIDAEMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/085108    International Application No.:    PCT/GB2006/000499
Publication Date: 17.08.2006 International Filing Date: 14.02.2006
IPC:
C07D 319/18 (2006.01), C07D 215/20 (2006.01), C07D 271/10 (2006.01), C07D 277/20 (2006.01), C07D 277/68 (2006.01), A61K 31/33 (2006.01), A61P 9/10 (2006.01)
Applicants: SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza, Po Box 7929, Philadelphia, Pennsylvania 19101 (US) (For All Designated States Except US).
CAMPBELL, Mathew [GB/GB]; (GB) (For US Only).
MASON, Andrew, Mcmurtrie [GB/GB]; (GB) (For US Only).
PINTO, Ivan, Leo [GB/GB]; (GB) (For US Only).
POLLARD, Derek, Roland [GB/GB]; (GB) (For US Only).
SMITH, Ian, Edward, David [GB/GB]; (GB) (For US Only)
Inventors: CAMPBELL, Mathew; (GB).
MASON, Andrew, Mcmurtrie; (GB).
PINTO, Ivan, Leo; (GB).
POLLARD, Derek, Roland; (GB).
SMITH, Ian, Edward, David; (GB)
Agent: THORNLEY, Rachel Mary; GlaxoSmithKline, Corporate Intellectual Property, 980 Great West Road, Brentford Middlesex TW8 9GS (GB)
Priority Data:
0503056.4 14.02.2005 GB
Title (EN) AWTHRANILIC ACID DERIVATIVES AND THEIR USE IN TREATMENT OF DISEASES OF LIPID METABOLISM, IN PARTICULAR DYSLIPIDAEMIA
(FR) DÉRIVÉS D'ACIDE ANTHRANILIQUE ET LEUR EMPLOI DANS LE TRAITEMENT DE MALADIES DU MÉTABOLISME LIPIDIQUE, EN PARTICULIER DE DYSLIPIDÉMIES
Abstract: front page image
(EN)Therapeutically active anthranilic acid derivatives of Formula (I) wherein R1, R2, W, Y and Z are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.
(FR)La présente invention porte sur des dérivés thérapeutiquement actifs d'acide anthranilique de Formule (I) où R1, R2, W, Y et Z sont tels que définis dans la description, ainsi que des procédés de préparation desdits dérivés, des formules pharmaceutiques contenant les composés actifs et l'emploi thérapeutique desdits composés, en particulier dans le traitement de maladies liées à la sous-activation du récepteur HM74A ou pour lesquelles l'activation dudit récepteur serait bénéfique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)