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1. (WO2006084904) TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084904    International Application No.:    PCT/EP2006/050859
Publication Date: 17.08.2006 International Filing Date: 10.02.2006
IPC:
C07D 495/04 (2006.01), A61K 31/4365 (2006.01), A61P 35/00 (2006.01)
Applicants: NYCOMED GMBH [DE/DE]; Byk-Gulden-Str. 2, 78467 Konstanz (DE) (For All Designated States Except US).
PEKARI, Klaus [DE/DE]; (DE) (For US Only).
SCHMIDT, Mathias [DE/DE]; (DE) (For US Only).
BÄR, Thomas [DE/DE]; (DE) (For US Only).
BECKERS, Thomas [DE/DE]; (DE) (For US Only).
BARTELS, Björn [DE/DE]; (DE) (For US Only)
Inventors: PEKARI, Klaus; (DE).
SCHMIDT, Mathias; (DE).
BÄR, Thomas; (DE).
BECKERS, Thomas; (DE).
BARTELS, Björn; (DE)
Agent: WILD, Robert; Nycomed GmbH, P.O. Box 100310, 78403 Konstanz (DE)
Priority Data:
05101007.2 11.02.2005 EP
05104493.1 25.05.2005 EP
05112159.8 14.12.2005 EP
Title (EN) TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER
(FR) TETRAHYDROPYRIDOTHIOPHENES EN TANT QU'AGENTS ANTIPROLIFERATIFS POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The invention relates to compounds of formula (I) wherein Ra is -C(O)ORI, in which R1 is 1-7C-a.kyl. 3-7C-cycoakyl, 1-7C-alkyl substituted by Raa, or 2-7C-alky substituted by Rab and Rac on different carbon atoms, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and Q is substituted by Rba and Rbb and Rbc, and is phenyl, wich are useful for the therapy of hyperprolif erative diseases, in particular human cancer.
(FR)La présente invention se rapporte à des composés de formule (I) dans laquelle Ra est -C(O)ORI, où R1 est un alkyle en C1-7, un cycloalkyle en C3-7, un alkyle en C1-7 portant une substitution Raa ou un alkyle en C2-7 portant des substitutions Rab et Rac sur différents atomes de carbone, et Rb est -T-Q, où T est un alkylène en C1-6 ou un cycloalkylène en C3-7 et Q est un phényle portant des substitutions Rba, Rbb et Rbc. Ces composés sont utiles pour le traitement des maladies hyperprolifératives, en particulier le cancer humain.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)