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1. (WO2006084854) [1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITH CYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084854    International Application No.:    PCT/EP2006/050744
Publication Date: 17.08.2006 International Filing Date: 08.02.2006
Chapter 2 Demand Filed:    28.08.2006    
IPC:
C07D 285/01 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), A61K 31/425 (2006.01), A61K 31/427 (2006.01), A61P 25/28 (2006.01)
Applicants: SOLVAY PHARMACEUTICALS B.V. [NL/NL]; C.j. Van Houtenlaan 36, NL-1381 CP Weesp (NL) (For All Designated States Except US).
FEENSTRA, Roelof W. [NL/NL]; (NL) (For US Only).
KEIZER, Hiskias G. [NL/NL]; (NL) (For US Only).
PRAS-RAVES, Maria L. [NL/NL]; (NL) (For US Only).
VAN VLIET, Bernard J. [NL/NL]; (NL) (For US Only).
VAN SCHARRENBURG, Gustaaf J.m. [NL/NL]; (NL) (For US Only)
Inventors: FEENSTRA, Roelof W.; (NL).
KEIZER, Hiskias G.; (NL).
PRAS-RAVES, Maria L.; (NL).
VAN VLIET, Bernard J.; (NL).
VAN SCHARRENBURG, Gustaaf J.m.; (NL)
Agent: VERHAGE, Marinus; Octrooibureau Zoan B.V., P.O. Box 140, NL-1380 AC Weesp (NL)
Priority Data:
60/651,661 11.02.2005 US
05101004.9 11.02.2005 EP
Title (EN) [1,2,4]-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITH CYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR
(FR) DERIVES DE [1,2,4]-DITHIAZOLI(DI)NE, INDUCTEURS DE LA GLUTHATHIONE-S-TRANSFERASE ET DE LA NADPH QUINONE OXYDOREDUCTASE, DESTINES A LA PROPHYLAXIE ET AU TRAITEMENT D'ETATS NOCIFS ASSOCIES A LA CYTOTOXICITE EN GENERAL ET, PLUS PARTICULIEREMENT, A L'APOPTOSE
Abstract: front page image
(EN)The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.
(FR)L'invention concerne des dérivés de 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine et de [1,2,4]- dithiazolidine-3,5-diylidène-diamine utilisés comme inducteurs de la glutha-thione-S- transférase (GST) et de la NADPH quinone oxydoréductase (NQO), des procédés de préparation de ces composés et des intermédiaires utiles pour la synthèse des dérivés de [1,2,4]-dithiazoli(di)ne. L'invention concerne également l'utilisation d'un composés selon l'invention pour la fabrication d'un médicament utile dans la prophylaxie et le traitement d'états nocifs associés à la cytotoxicité en général et, plus particulièrement, à l'apoptose. L'invention concerne enfin des composés de formule générale (I) dans laquelle les symboles ont les significations données dans la description.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)