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1. (WO2006084711) NOVEL GENE STS 22
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084711    International Application No.:    PCT/EP2006/001206
Publication Date: 17.08.2006 International Filing Date: 10.02.2006
C12N 15/11 (2006.01), C07K 14/705 (2006.01)
Applicants: DSM IP ASSETS B.V. [NL/NL]; Het Overloon 1, NL-6411 TE Heerlen (NL) (For All Designated States Except US).
BEUZELIN OLLIVIER, Marie-Gabrielle [FR/CH]; (CH) (For US Only).
CHEVREUX, Bastien [FR/DE]; (DE) (For US Only).
DALLUEGE, Manuela [DE/DE]; (DE) (For US Only).
GOESE, Markus [DE/CH]; (CH) (For US Only).
LEE, Connie [US/IS]; (IS) (For US Only).
MEURY, Anja [CH/CH]; (CH) (For US Only).
MOUNCEY, Nigel, John [GB/CH]; (CH) (For US Only).
SHINJOH, Masako [JP/JP]; (JP) (For US Only)
Inventors: BEUZELIN OLLIVIER, Marie-Gabrielle; (CH).
CHEVREUX, Bastien; (DE).
DALLUEGE, Manuela; (DE).
GOESE, Markus; (CH).
LEE, Connie; (IS).
MEURY, Anja; (CH).
MOUNCEY, Nigel, John; (CH).
SHINJOH, Masako; (JP)
Agent: SCHWANDER, Kuno Josef; DSM Nutritional Products Ltd, Wurmisweg 576, CH-4303 Kaiseraugst (CH)
Priority Data:
05405088.5 11.02.2005 EP
05405066.1 11.02.2005 EP
Abstract: front page image
(EN)The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct roduction of Vitamin C.
(FR)La présente invention concerne des gènes nouvellement identifiés codant pour des protéines impliquées dans la synthèse de l'acide ascorbique L (appelée également vitamine C). Cette invention concerne aussi des polynucléotides comprenant des séquences de polynucléotides de pleine longueur de ces nouveaux gènes et des fragments de ceux-ci, des nouveaux polypeptides codés par ces polynucléotides et des fragments de ceux-ci, ainsi que leurs équivalents fonctionnels. Cette invention concerne aussi l'utilisation de ces polynucléotides et de ces polypeptides comme outils biotechnologiques dans la production de la vitamine C à partir de micro-organismes, une modification de ces polynucléotides et/ou de ces polypeptides codés ayant un impact direct ou indirect sur le rendement, la production et/ou l'efficacité de la production du produit de fermentation dans ce micro-organisme. Cette invention concerne aussi des techniques/processus d'utilisation de ces polynucléotides et de ces séquences de polynucléotides modifiés destinés à transformer des micro-organismes hôtes. Cette invention concerne enfin des micro-organismes génétiquement modifiés et leur utilisation pour la production directe de vitamine C.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)