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Pub. No.:    WO/2006/084701    International Application No.:    PCT/EP2006/001193
Publication Date: 17.08.2006 International Filing Date: 10.02.2006
C12N 9/12 (2006.01), C12P 17/04 (2006.01)
Applicants: DSM IP ASSETS B.V. [NL/NL]; Het Overloon 1, NL-6411 TE Heerlen (NL) (For All Designated States Except US).
BEUZELIN OLLIVIER, Marie-Gabrielle [FR/CH]; (CH) (For US Only).
CHEVREUX, Bastien [FR/DE]; (DE) (For US Only).
DALLUEGE, Manuela [DE/DE]; (DE) (For US Only).
GOESE, Markus [DE/CH]; (CH) (For US Only).
LEE, Connie [US/IS]; (IS) (For US Only).
MEURY, Anja [CH/CH]; (CH) (For US Only).
MOUNCEY, Nigel John [GB/CH]; (CH) (For US Only).
SHINJOH, Masako [JP/JP]; (JP) (For US Only)
Inventors: BEUZELIN OLLIVIER, Marie-Gabrielle; (CH).
CHEVREUX, Bastien; (DE).
DALLUEGE, Manuela; (DE).
GOESE, Markus; (CH).
LEE, Connie; (IS).
MEURY, Anja; (CH).
MOUNCEY, Nigel John; (CH).
SHINJOH, Masako; (JP)
Agent: SCHWANDER, Kuno, Josef; DSM Nutritional Products Ltd, Wurmisweg 576, CH-4303 Kaiseraugst (CH)
Priority Data:
05405087.7 11.02.2005 EP
05405066.1 11.02.2005 EP
Abstract: front page image
(EN)The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
(FR)La présente invention concerne des gènes récemment identifiés codant des protéines impliquées dans la synthèse de l’acide L-ascorbique (également désigné ci-après par Vitamine C). L’invention concerne en outre des polynucléotides comprenant les séquences polynucléotides pleine longueur des nouveaux gènes et leurs fragments, les nouveaux polypeptides codés par les polynucléotides et leurs fragments, ainsi que leurs équivalents fonctionnels. La présente invention concerne en outre l’utilisation desdits polynucléotides et polypeptides comme outils biotechnologiques lors de la production de Vitamine C à partir de microorganismes, une modification desdits polynucléotides et/ou polypeptides codés ayant un impact direct ou indirect sur le rendement, la production et/ou l’efficacité de la production du produit de fermentation dans ledit microorganisme. L’invention concerne également des méthodes/procédés d’utilisation des polynucléotides et des séquences polynucléotides modifiées en vue de transformer des microorganismes hôtes. L’invention concerne en outre des microorganismes génétiquement modifiés et leur utilisation pour produire directement de la Vitamine C.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)