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Machine translation
1. (WO2006084471) METHOD OF RATIONAL DRUG DESIGN BASED ON BINDING ABILITY WITH ELONGATION FACTOR TU
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084471    International Application No.:    PCT/DK2006/000077
Publication Date: 17.08.2006 International Filing Date: 09.02.2006
IPC:
G06F 17/50 (2006.01), G01N 33/50 (2006.01)
Applicants: AARHUS UNIVERSITET [DK/DK]; Ndr. Ringgade 1, DK-8000 Aarhus C (DK) (For All Designated States Except US).
NISSEN, Poul [DK/DK]; (DK) (For US Only).
PARMEGGIANI, Andrea [IT/IT]; (IT) (For US Only)
Inventors: NISSEN, Poul; (DK).
PARMEGGIANI, Andrea; (IT)
Agent: PLOUGMANN & VINGTOFT A/S; Sundkrogsgade 9, P.O. Box 831, DK-2100 Copenhagen_Ø (DK)
Priority Data:
PA 2005 00189 09.02.2005 DK
Title (EN) METHOD OF RATIONAL DRUG DESIGN BASED ON BINDING ABILITY WITH ELONGATION FACTOR TU
(FR) METHODE DE CONCEPTION DE MEDICAMENT RATIONNELLE FONDEE SUR LA CAPACITE DE LIAISON AU FACTEUR D'ALLONGEMENT TU
Abstract: front page image
(EN)The invention relates to a method of rational drug design based upon the surprising discovery that the structurally very different antibiotics enacyloxin Ha and kirromycin bind with Elongation Factor Tu (EF-Tu) in a similar manner. This allows for new chemical entities and new antibiotics to be developed. The invention defines a method for designing new antibiotics which are structural hybrids of enacyloxin IIa and kirromycin; the new antibiotics combining critical moieties of each of the parent molecules.
(FR)L'invention concerne une méthode de conception de médicament rationnelle. Cette méthode est fondée sur la découverte surprenante selon laquelle les antibiotiques énacyloxine Ha et kirromycine, qui sont structurellement très différents, se lient au facteur d'allongement Tu (EF-Tu) de manière analogue. Ceci permet à de nouvelles entités chimiques et à de nouveaux antibiotiques d'être élaborés. L'invention concerne une méthode pour concevoir de nouveaux antibiotiques qui sont des hybrides structuraux de l'énacyloxine IIa et de la kirromycine. Ces antibiotiques combinent des fractions critiques de chaque molécule parent.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)