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1. (WO2006084216) OPTIMIZED PROBE SELECTION METHOD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084216    International Application No.:    PCT/US2006/004017
Publication Date: 10.08.2006 International Filing Date: 03.02.2006
IPC:
G06F 19/20 (2011.01)
Applicants: NIMBLEGEN SYSTEMS, INC. [US/US]; 1 Science Court, Madison, WI 53711 (US) (For All Designated States Except US).
RICHMOND, Todd [US/US]; (US) (For US Only).
NORTON, Jason [US/US]; (US) (For US Only).
NUWAYSIR, Emile, F. [US/US]; (US) (For US Only).
GREEN, Roland [US/US]; (US) (For US Only).
NUWAYSIR, Kate [US/US]; (US) (For US Only)
Inventors: RICHMOND, Todd; (US).
NORTON, Jason; (US).
NUWAYSIR, Emile, F.; (US).
GREEN, Roland; (US).
NUWAYSIR, Kate; (US)
Agent: VINAROV, Sara; Quarles & Brady LLP, P O Box 2113, Madison, WI 53701-2113 (US)
Priority Data:
60/650,265 04.02.2005 US
Title (EN) OPTIMIZED PROBE SELECTION METHOD
(FR) PROCEDE DE SELECTION DE SONDES OPTIMISEES
Abstract: front page image
(EN)The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.
(FR)La présente invention se rapporte à des procédés permettant d'optimiser des sondes d'hybridation oligonucléotidiques, qui sont destinés à la recherche fondamentale et clinique. Précisément, l'invention consiste à hybrider un échantillon génomique dilué en série avec les sondes oligonucléotidiques sur le réseau, de façon qu'une intensité de signal soit produite pour chacune des sondes, et à identifier par calcul des sondes optimisées, qui présentent des intensités de signal correspondant aux dilutions en série de l'échantillon génomique, et sont résistantes et reproductibles par rapport aux sondes non optimisées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)