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Machine translation
1. (WO2006084210) HIF MODULATING COMPOUNDS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084210    International Application No.:    PCT/US2006/004004
Publication Date: 10.08.2006 International Filing Date: 03.02.2006
IPC:
A61P 7/00 (2006.01), A61P 31/00 (2006.01), A61P 31/04 (2006.01), A61P 31/12 (2006.01), A61P 35/00 (2006.01), A61P 37/04 (2006.01)
Applicants: REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO [US/US]; 1111 Franklin Street, 5th Floor, Oakland, California 94607-5200 (US) (For All Designated States Except US).
JOHNSON, Randall, S. [US/US]; (US) (For US Only).
PEYSSONNAUX, Carole [US/US]; (US) (For US Only).
NIZET, Victor [US/US]; (US) (For US Only).
THEODORAKIS, Emmanuel [US/US]; (US) (For US Only)
Inventors: JOHNSON, Randall, S.; (US).
PEYSSONNAUX, Carole; (US).
NIZET, Victor; (US).
THEODORAKIS, Emmanuel; (US)
Agent: STEFFEY, Charles, E.; Schwegman, Lundberg, Woessner & Kluth, P.A., P.O. Box 2938, Minneapolis, Minnesota 55402 (US)
Priority Data:
60/649,544 04.02.2005 US
Title (EN) HIF MODULATING COMPOUNDS AND METHODS OF USE THEREOF
(FR) COMPOSES MODULANT LE HIF ET METHODES D'UTILISATION ASSOCIEES
Abstract: front page image
(EN)A method is provided for treating subjects, including humans, with infection or virulence by pathogens. The method involves administering an agent in amounts effective to eradicate or reduce infections and/or an inflammatory response caused by pathogens. Methods for identifying compounds useful as anti-infectives that decrease the immune resistance, virulence, or growth of microbes are also provided. More particularly, there are provided methods for identifying compounds which increase accumulation or stability or activity, or alternatively decrease the degradation of HIF-1a protein.
(FR)L'invention concerne une méthode destinée à traiter des sujets, notamment des humains, présentant une infection ou une virulence d'agents pathogènes. Cette méthode consiste à administrer un agent dans une quantité efficace pour éradiquer ou réduire des infections et/ou une réaction inflammatoire causée par des agents pathogènes. L'invention concerne également des procédés d'identification de composés utiles en tant qu'agents anti-infectieux réduisant la résistance immunitaire, la virulence ou la croissance de microbes. L'invention concerne plus particulièrement des procédés d'identification de composés augmentant l'accumulation ou la stabilité ou l'activité de la protéine HIF-1$g(a), ou réduisant en variante la dégradation de cette protéine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)