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1. (WO2006084191) LOCAL GENE THERAPY WITH AN ELUTING STENT FOR VASCULAR INJURY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/084191    International Application No.:    PCT/US2006/003963
Publication Date: 10.08.2006 International Filing Date: 03.02.2006
IPC:
A61K 31/70 (2006.01), A61F 2/00 (2006.01), C07H 21/04 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor, Oakland, California 94607-5200 (US) (For All Designated States Except US).
CHIEN, Shu [US/US]; (US) (For US Only)
Inventors: CHIEN, Shu; (US)
Agent: HAILE, Lisa, A.; DLA Piper Rudnick Gray Cary US LLP, 4365 Executive Drive, Suite 1100, San Diego, California 92121-2133 (US)
Priority Data:
60/650,069 04.02.2005 US
Title (EN) LOCAL GENE THERAPY WITH AN ELUTING STENT FOR VASCULAR INJURY
(FR) THERAPIE GENIQUE LOCALE AYANT UN STENT D'ELUTION POUR LESIONS VASCULAIRES
Abstract: front page image
(EN)The present invention relates to a method for preventing or treating stenosis or restenosis in subjects by placement of a polymerized support delivering a recombinant adeno or adeno-associated vector with a mutant Ras nucleic acid encoding a mutant Ras protein which inhibits Ras-mediated phosphorylation, and blocking the Ras signal transduction pathway in vascular smooth muscle cells (VSMCs).
(FR)L'invention concerne une méthode de prévention ou de traitement de la sténose ou de la resténose chez les sujets par la mise en place d'un support polymérisé administrant un vecteur recombinant adéno ou adéno-associé avec un acide nucléique mutant Ras codant une protéine mutante Ras qui inhibe la phosporylation induite par Ras et par le blocage de la voie de transduction du signal Ras dans les cellules vasculaires de muscles souples (VSMC).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)