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1. (WO2006083957) TAT-001 AND METHODS OF ASSESSING AND TREATING CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/083957    International Application No.:    PCT/US2006/003543
Publication Date: 10.08.2006 International Filing Date: 31.01.2006
IPC:
C07K 14/82 (2006.01), C07K 16/30 (2006.01), C12P 21/06 (2006.01)
Applicants: CAPRION PHARMACEUTICALS, INC. [CA/CA]; 7150 Alexander-fleming, Saint Laurent, Quebec, H4S 2C8 (CA) (For All Designated States Except US).
KEARNEY, Paul [CA/CA]; (CA) (For US Only).
BUTLER, Heather [CA/CA]; (CA) (For US Only).
JAITLY, Navdeep [CA/US]; (US) (For US Only).
SWAMY, Sajani [CA/CA]; (CA) (For US Only).
HAMAIDI, Lyes [CA/CA]; (CA) (For US Only).
FILGUEIRA, Marcelo [CA/CA]; (CA) (For US Only).
THIBAULT, Pierre [CA/CA]; (CA) (For US Only).
FAUBERT, Denis [CA/CA]; (CA) (For US Only).
CHELSKY, Daniel [US/CA]; (CA) (For US Only).
LANOIX, Joel [CA/CA]; (CA) (For US Only).
BRUNET, Sylvain [CA/CA]; (CA) (For US Only).
ENG, Kevin [CA/CA]; (CA) (For US Only).
AGUILERA, Frank [CA/CA]; (CA) (For US Only).
TSANG, John [CA/US]; (US) (For US Only).
HU, Michael [CA/US]; (US) (For US Only).
OSTERMANN, Joachim [DE/CA]; (CA) (For US Only).
BOULOS, Marguerite [CA/CA]; (CA) (For US Only)
Inventors: KEARNEY, Paul; (CA).
BUTLER, Heather; (CA).
JAITLY, Navdeep; (US).
SWAMY, Sajani; (CA).
HAMAIDI, Lyes; (CA).
FILGUEIRA, Marcelo; (CA).
THIBAULT, Pierre; (CA).
FAUBERT, Denis; (CA).
CHELSKY, Daniel; (CA).
LANOIX, Joel; (CA).
BRUNET, Sylvain; (CA).
ENG, Kevin; (CA).
AGUILERA, Frank; (CA).
TSANG, John; (US).
HU, Michael; (US).
OSTERMANN, Joachim; (CA).
BOULOS, Marguerite; (CA)
Agent: ELBING, Karen; CLARK & ELBING LLP, 101 Federal Street, Boston, Massachusetts 02110 (US)
Priority Data:
60/648,758 31.01.2005 US
Title (EN) TAT-001 AND METHODS OF ASSESSING AND TREATING CANCER
(FR) TAT-001 ET METHODES D'EVALUATION ET DE TRAITEMENT D'UN CANCER
Abstract: front page image
(EN)Surprisingly, the present inventors have discovered that expression of TAT- 001 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-001 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-001 expression or activity, comprising: contacting a candidate compound with a TAT-001 and detecting the presence or absence of binding between said compound and said TAT-001, or detecting a change in TAT-001 expression or activity. Methods are also included for the identification of anti-cancer compounds and compounds that modulate TAT-001 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-001 expression or activity.
(FR)La présente invention concerne la découverte, selon laquelle l'expression de la protéine TAT- 001 chez des patients humains est liée au cancer et que la surexpression protéique est présente dans des fractions membranaires du plasma. De ce fait, TAT-001 est liée à une croissance et à un développement anormaux et elle peut être utilisée en tant que cible d'identification de composés anticancéreux, y compris, des anticorps utilisés en immunothérapie. Par conséquent, cette invention a trait à des méthodes d'identification de composés inhibant l'expression ou l'activité de TAT-001 qui consistent à mettre en contact un composé candidat avec TAT-001 et à détecter la présence ou l'absence de liaison entre ledit composé et TAT-001 ou à détecter un changement dans l'expression ou l'activité de TAT-001. Enfin, ladite invention a pour objet des méthodes d'identification de composés anticancéreux et des composés qui servent à moduler l'expression ou l'activité de TAT-001, lesdites méthodes consistant à administrer un composé à une cellule ou à une population cellulaire et à détecter un changement dans l'expression ou l'activité de TAT-001.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)