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1. (WO2006083797) IMPROVING AND PROTECTING CELL THERAPY FOR NEUROLOGICAL DISORDERS INCLUDING PARKINSON'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/083797    International Application No.:    PCT/US2006/003295
Publication Date: 10.08.2006 International Filing Date: 31.01.2006
IPC:
A61K 48/00 (2006.01), C12N 5/10 (2006.01), C12N 15/63 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library, 535 West 116th Street, New York, NY 10027 (US) (For All Designated States Except US).
ABELIOVICH, Asa [US/US]; (US) (For US Only).
MARTINAT, Cecile [FR/US]; (US) (For US Only)
Inventors: ABELIOVICH, Asa; (US).
MARTINAT, Cecile; (US)
Agent: KIM, William; Wilmer Cutler Pickering Hale and Dorr LLP, 399 Park Avenue, New York, NY 10022 (US)
Priority Data:
11/048,391 31.01.2005 US
Title (EN) IMPROVING AND PROTECTING CELL THERAPY FOR NEUROLOGICAL DISORDERS INCLUDING PARKINSON'S DISEASE
(FR) AMELIORATION ET PROTECTION EN THERAPIE CELLULAIRE DANS LE CAS DE TROUBLES NEUROLOGIQUES Y COMPRIS LA MALADIE DE PARKINSON
Abstract: front page image
(EN)The present invention provides compositions and methods for enhancing and improving cell therapies for neurological disorders including Parkinson's disease. Specifically, the present invention provides a cell or cells modified by viral vector compositions that allow for the over-expression and RNAi mediated knockdown of genes in vitro and in vivo. The present invention further provides cell therapy methods for treating or preventing neurodegeneration in a subject, and for protecting neurons from damage in the context of neurodegenerative disorders using the modified cells. Additionally, the present invention provides methods for purification and identification of mature dopamine neurons for cell therapy using fluorescent compounds including JHCl-64.
(FR)L'invention concerne des compositions et des procédés destinés à activer et à améliorer les thérapies cellulaires dans le cas de troubles neurologiques y compris la maladie de Parkinson. Spécifiquement, l'invention concerne une ou plusieurs cellules modifiées par des compositions à vecteur viral, tenant compte de la surexpression des gènes et de l'inactivation des gènes occasionnée par ARNi in vitro et in vivo. L'invention concerne en outre des procédés de thérapie cellulaire pour le traitement ou la prévention d'une neurodégénérescence chez un sujet, ainsi que pour protéger les neurones d'une défaillance, dans le contexte de troubles neurodégénérescents, au moyen des cellules modifiées. De plus, l'invention concerne des procédés de purification et d'identification de neurones à dopamine mature, en thérapie cellulaire au moyen de composés fluorescents comprenant JHCI-64.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)