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Machine translation
1. (WO2006083780) GLUCURONIDATED NEBIVOLOL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/083780    International Application No.:    PCT/US2006/003253
Publication Date: 10.08.2006 International Filing Date: 30.01.2006
Chapter 2 Demand Filed:    20.11.2006    
IPC:
C07H 7/033 (2006.01), A61K 31/7012 (2006.01), A61P 9/00 (2006.01), A61P 9/08 (2006.01)
Applicants: MYLAN LABORATORIES, INC. [US/US]; 781 Chestnut Ridge Road, Morgantown, WV 26504 (US) (For All Designated States Except US).
O'DONNELL, John, P. [US/US]; (US) (For US Only).
OWENS, Walter [US/US]; (US) (For US Only).
DUNCAN, Joseph [US/US]; (US) (For US Only).
SHAW, Andrew [US/US]; (US) (For US Only)
Inventors: O'DONNELL, John, P.; (US).
OWENS, Walter; (US).
DUNCAN, Joseph; (US).
SHAW, Andrew; (US)
Agent: SCHNAPP, Karlyn, A.; FROST BROWN TODD LLC, 201 East Fifth Street, 2200 PNC Center, Cincinnati, OH 45202 (US)
Priority Data:
60/648,552 31.01.2005 US
60/755,755 03.01.2006 US
Title (EN) GLUCURONIDATED NEBIVOLOL
(FR) METABOLITES DE NEBIVOLOL GLYCUROCONJUGUES
Abstract: front page image
(EN)This invention provides glucuronidated nebivolol metabolites and pharmaceutical compositions of glucuronidated nebivolol for treatment of cardiovascular diseases. In addition, this invention also provides compositions comprising nebivolol and/or at least one glucuronidated metabolite of nebivolol and/or at least one other active compound in a pharmaceutically acceptable carrier. This invention also provides methods of treating and/or preventing vascular diseases, by administering at least one glucuronidated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease.
(FR)La présente invention concerne des métabolites de nebivolol glycuroconjugués et des compositions pharmaceutiques de métabolites de nebivolol glycuroconjugués destinés au traitement de maladies cardio-vasculaires. Cette invention concerne aussi le nebivolol et/ou au moins un métabolite glycuroconjugué de nebivolol et/ou au moins un autre composé actif dans un porteur répondant aux normes pharmaceutiques. Cette invention concerne aussi des techniques de traitement et/ou de prévention de maladies vasculaires par administration d'une quantité thérapeutiquement efficace d'oxyde nitrique sur un site ciblé affecté par une maladie vasculaire. Cette invention concerne aussi le traitement et/ou la prévention de migraine par l'administration d'au moins un métabolite glycuroconjugué de nebivolol. Cette invention peut être utilisée avec un autre traitement ou sous forme de traitement unique de troubles de syndrome métabolique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)