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1. (WO2006083721) PURIFICATION PROCESS FOR PIASMID DNA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/083721    International Application No.:    PCT/US2006/003015
Publication Date: 10.08.2006 International Filing Date: 27.01.2006
IPC:
C12Q 1/68 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
BOYD, David, B. [US/US]; (US) (For US Only).
KRISTOPEIT, Adam Joel [US/US]; (US) (For US Only).
LANDER, Russel Jackson [US/US]; (US) (For US Only).
MURPHY, Jason, C. [US/US]; (US) (For US Only).
WINTERS, Michael Albert [US/US]; (US) (For US Only)
Inventors: BOYD, David, B.; (US).
KRISTOPEIT, Adam Joel; (US).
LANDER, Russel Jackson; (US).
MURPHY, Jason, C.; (US).
WINTERS, Michael Albert; (US)
Agent: GINKEL, Laura, M.; MERCK & CO., INC., 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
60/648,670 31.01.2005 US
Title (EN) PURIFICATION PROCESS FOR PIASMID DNA
(FR) PROCEDE DE PURIFICATION AMONT ET AVAL POUR PRODUCTION A LARGE ECHELLE D'ADN PLASMIDIQUE
Abstract: front page image
(EN)Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both of the purification processes disclosed herein may be used in combination with additional purification steps known in the art that are associated with DNA plasmid purification technology.
(FR)L'invention concerne des procédés destinés à isoler un ADN plasmidique de qualité clinique à partir de procédés de fabrication, y compris des régimes de fermentation à large échelle, et incluant des variantes aux deux opérations unitaires de base communes aux procédés de purification d'ADN. Les nouveaux procédés de purification amont et aval de l'invention permettent de réduire les coûts de production et d'augmenter la robustesse du procédé. L'un ou l'autre de ces procédés de purification ou les deux peuvent être utilisés en combinaison avec des étapes de purification supplémentaires connues dans la technique qui sont associées à la technologie de purification de plasmide d'ADN.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)