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1. (WO2006083689) ANTI A BETA ANTIBODY FORMULATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/083689    International Application No.:    PCT/US2006/002837
Publication Date: 10.08.2006 International Filing Date: 27.01.2006
Chapter 2 Demand Filed:    27.11.2006    
IPC:
A61K 39/395 (2006.01), C07K 16/18 (2006.01)
Applicants: ELAN PHARMA INTERNATIONAL LIMITED [IE/IE]; Monksland, Athlone, County Westmeath (IE) (For All Designated States Except US).
WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
LUISI, Donna [US/US]; (US) (For US Only).
WARNE, Nicholas, W. [US/US]; (US) (For US Only).
KANTOR, Angela [US/US]; (US) (For US Only)
Inventors: LUISI, Donna; (US).
WARNE, Nicholas, W.; (US).
KANTOR, Angela; (US)
Agent: MILASINCIC, Debra, J.; Lahive & Cockfield, LLP, One Post Office Square, Boston, MA 02109-2127 (US)
Priority Data:
60/648,631 28.01.2005 US
Title (EN) ANTI A BETA ANTIBODY FORMULATION
(FR) PREPARATION D'ANTICORPS ANTI-A$G(B)
Abstract: front page image
(EN)The present invention provides formulations for maintaining the stability of A&bgr; binding polypeptides, for example, A&bgr; antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.
(FR)La présente invention concerne des préparations permettant de maintenir la stabilité de polypeptides de liaison Aß, par ex., des anticorps anti-Aß. Des préparations exemplaires renferment un agent de tonicité, tel que le mannitol, et un agent tampon ou un acide aminé, tel que l'histidine. D'autres préparations exemplaires contiennent un antioxydant dans une quantité suffisante de manière à inhiber la formation de sous-produits, par exemple, la formation d'agrégats de polypeptides à poids moléculaire élevé, de fragments de dégradation de polypeptides à poids moléculaire faible et des mélanges associés. Les préparations de cette invention renferment, facultativement, un agent de tonicité, tel que le mannitol, et un agent tampon ou un acide aminé, tel que l'histidine. Ces préparations sont appropriées à plusieurs différentes voies d'administration.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)