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Machine translation
1. (WO2006083301) IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/083301    International Application No.:    PCT/US2005/021691
Publication Date: 10.08.2006 International Filing Date: 16.06.2005
IPC:
C12P 21/06 (2006.01), C12N 15/74 (2006.01), C07K 14/00 (2006.01), C07K 16/00 (2006.01)
Applicants: MEDIMMUNE, INC. [US/US]; One Medimmune Way, Gaithersburg, Maryland 20878 (US) (For All Designated States Except US).
MESSMER, Davorka [DE/US]; (US) (For US Only).
TRACEY, Kevin [US/US]; (US) (For US Only).
KIENER, Peter [US/US]; (US) (For US Only).
ALBAN, Scott [US/US]; (US) (For US Only).
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH [US/US]; 350 Community Drive, Manhasset, NY 11030 (US) (For All Designated States Except US)
Inventors: MESSMER, Davorka; (US).
TRACEY, Kevin; (US).
KIENER, Peter; (US).
ALBAN, Scott; (US)
Agent: MARTINEAU, Janet; MEDIMMUNE, INC., One Medimmune Way, Gaithersburg, Maryland 20878 (US)
Priority Data:
60/580,549 17.06.2004 US
Title (EN) IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES
(FR) COMPOSITIONS IMMUNOGENIQUES COMPRENANT DES POLYPEPTIDES HMGB1
Abstract: front page image
(EN)The present invention relates to novel immunogenic compositions (e.g., vaccines), the production of such immunogenic compositions and methods of using such compositions. More specially, this invention provides unique immunogenic molecules comprising an HMGB1 polypeptide (e.g., an HMGB1 B-box polypeptide) and an antigen. Even more specificially, this invention provides novel fusion proteins comprising an isolated HMGB1 polypeptide and an antigen such that administration of these fusion proteins provides the two signals required for native T - cell activation.
(FR)Cette invention se rapporte à de nouvelles compositions immunogéniques (p. ex. des vaccins), à la production desdites compositions immunogéniques et à des procédés d'utilisation desdites compositions. Plus particulièrement, cette invention concerne des molécules immunogéniques uniques comprenant un polypeptide HMGB1 (p. ex. un polypeptide HMGB1 B-box) et un antigène. Cette invention concerne encore plus particulièrement de nouvelles protéines de fusion comprenant un polypeptide HMGB1 isolé et un antigène, l'administration de ces protéines de fusion permettant de fournir les deux signaux nécessaires à l'activation des lymphocytes T natifs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)