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1. (WO2006082978) ACYLAMIDE COMPOUND WITH ACTION OF ENHANCING SECRETION OF ADIPONECTIN OR INDUCING ADIPONECTIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/082978    International Application No.:    PCT/JP2006/302058
Publication Date: 10.08.2006 International Filing Date: 07.02.2006
IPC:
C07C 233/47 (2006.01), C07C 233/49 (2006.01), C07C 233/52 (2006.01), C07C 237/22 (2006.01), C07C 323/59 (2006.01), A23L 1/30 (2006.01), A23L 2/00 (2006.01), A61K 31/198 (2006.01)
Applicants: AJINOMOTO CO., INC. [JP/JP]; 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315 (JP) (For All Designated States Except US).
MAEZONO, Katsumi [JP/JP]; (JP) (For US Only).
YOSHIMURA, Toshihiko [JP/JP]; (JP) (For US Only).
ISHIDA, Nozomu [JP/JP]; (JP) (For US Only).
FUKUCHI, Naoyuki [JP/JP]; (JP) (For US Only).
HATANAKA, Toshihiro [JP/JP]; (JP) (For US Only).
IKEHARA, Osamu [JP/JP]; (JP) (For US Only).
KAWATO, Yayoi [JP/JP]; (JP) (For US Only).
TANAKA, Hideyuki [JP/JP]; (JP) (For US Only)
Inventors: MAEZONO, Katsumi; (JP).
YOSHIMURA, Toshihiko; (JP).
ISHIDA, Nozomu; (JP).
FUKUCHI, Naoyuki; (JP).
HATANAKA, Toshihiro; (JP).
IKEHARA, Osamu; (JP).
KAWATO, Yayoi; (JP).
TANAKA, Hideyuki; (JP)
Agent: KUMAKURA, Yoshio; NAKAMURA & PARTNERS Shin-Tokyo Bldg. 3-1, Marunouchi 3-chome Chiyoda-ku, Tokyo 100-8355 (JP)
Priority Data:
2005-030828 07.02.2005 JP
Title (EN) ACYLAMIDE COMPOUND WITH ACTION OF ENHANCING SECRETION OF ADIPONECTIN OR INDUCING ADIPONECTIN
(FR) COMPOSE ACYLAMIDE DONT L'ACTION CONSISTE A AUGMENTER LA SECRETION DE L’ADIPONECTINE OU A DECLENCHER L’ADIPONECTINE
(JA) アディポネクチンの分泌促進または誘導作用を有するアシルアミド化合物
Abstract: front page image
(EN)It is intended to provide an acylamide compound represented by the following formula (1), a pro-drug thereof or a pharmaceutically acceptable salt thereof and an adiponectin inducer, an adiponectin secretion enhancer, a metabolic syndrome therapeutic agent, a hypoadiponectinemia therapeutic agent, a hyperlipemia therapeutic agent, a diabetes preventive/therapeutic agent, an impaired glucose tolerance ameliorating agent, an insulin sensitizer, an insulin sensitivity enhancer, a hypertension therapeutic agent, an angiopathy preventive/therapeutic agent or an anti-inflammatory agent, a hepatitis therapeutic agent, a steatosis therapeutic agent, a liver fibrosis therapeutic agent, a hepatic cirrhosis therapeutic agent, a preventive/therapeutic agent for non-alcoholic/nonviral steatohepatitis (NASH) or non-alcoholic/nonviral fatty liver disease (NAFLD) or an obesity therapeutic agent that contains any of these compounds as an active ingredient.
(FR)Cette invention concerne un composé acylamide représenté par la formule suivante (1), une pro-drogue de celui-ci ou un sel pharmaceutiquement acceptable de celui-ci et un inducteur de l’adiponectine, un activateur de la sécrétion de l’adiponectine, un agent thérapeutique du syndrome métabolique, un agent thérapeutique de l’hypoadiponectinémie, un agent thérapeutique de l’hyperlipidémie, un agent thérapeutique/de prévention du diabète, un agent améliorant la diminution de tolérance au glucose, un sensibilisateur insulinique, un activateur de la sensibilité insulinique, un agent thérapeutique de l’hypertension, un agent thérapeutique/de prévention de l’angiopathie ou un agent anti-inflammatoire, un agent thérapeutique de l’hépatite, un agent thérapeutique de la stéatose, un agent thérapeutique de la fibrose hépatique, un agent thérapeutique de la cirrhose, un agent thérapeutique/de prévention de la stéatohépatite non-alcoolique/non-virale (NASH) ou de la toxémie de gestation de la vache non- alcoolique/non-virale (NAFLD) ou un agent thérapeutique de l’obésité qui contient l’un ou l’autre de ces composés en tant qu’ingrédient actif.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)