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1. (WO2006082975) OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/082975    International Application No.:    PCT/JP2006/302024
Publication Date: 10.08.2006 International Filing Date: 07.02.2006
IPC:
C07D 401/12 (2006.01), A61K 31/4439 (2006.01), A61P 1/16 (2006.01), A61P 1/18 (2006.01), A61P 9/10 (2006.01), A61P 11/00 (2006.01), A61P 13/12 (2006.01), A61P 17/06 (2006.01), A61P 19/02 (2006.01), A61P 25/28 (2006.01), A61P 29/00 (2006.01), A61P 31/04 (2006.01), A61P 37/06 (2006.01), A61P 37/08 (2006.01), C07D 231/12 (2006.01), C07D 401/14 (2006.01)
Applicants: MITSUBISHI PHARMA CORPORATION [JP/JP]; Intellectual Property Department 2-6, Nihonbashi-honcho 2-chome Chuo-ku, Tokyo 103-8405 (JP) (For All Designated States Except US).
NAKAMURA, Mitsuharu [JP/JP]; (JP) (For US Only).
ISHIBUCHI, Seigo [JP/JP]; (JP) (For US Only).
OHTSUKA, Tatsuyuki [JP/JP]; (JP) (For US Only).
SUMICHIKA, Hiroshi [JP/JP]; (JP) (For US Only).
SEKIGUCHI, Sumie [JP/JP]; (JP) (For US Only).
ISHIGE, Takayuki [JP/JP]; (JP) (For US Only).
UEDA, Naoko [JP/JP]; (JP) (For US Only)
Inventors: NAKAMURA, Mitsuharu; (JP).
ISHIBUCHI, Seigo; (JP).
OHTSUKA, Tatsuyuki; (JP).
SUMICHIKA, Hiroshi; (JP).
SEKIGUCHI, Sumie; (JP).
ISHIGE, Takayuki; (JP).
UEDA, Naoko; (JP)
Priority Data:
2005-029907 07.02.2005 JP
Title (EN) OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE
(FR) DERIVE DE TETRAHYDRONAPHTALENE OPTIQUEMENT ACTIF
(JA) 光学活性なテトラヒドロナフタレン誘導体
Abstract: front page image
(EN)Compound that as compared with the racemate thereof, is highly enhanced in not only C5a receptor antagonistic activity but also extent of bioavailability, represented by the formula (I). Further, there are provided its pharmacologically acceptable salts, or hydrates or solvates thereof.
(FR)La présente invention concerne un composé qui, par comparaison avec son racémate, présente non seulement une activité antagoniste du récepteur du C5a fortement amplifiée mais également un degré de biodisponibilité fortement accru. Ce composé est représenté par la formule: [Formule Chimique 1] (I). L'invention concerne en outre les sels, les hydrates ou les solvates pharmacologiquement acceptables de ce composé.
(JA) そのラセミ体と比較し、C5a受容体拮抗活性のみならず、生物学的利用率においても高活性を示す、 下記式(I)で示される化合物若しくはその薬理学的に許容される塩又はそれらの水和物若しくは溶媒和物。 【化1】  
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)