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1. (WO2006082404) COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/082404    International Application No.:    PCT/GB2006/000352
Publication Date: 10.08.2006 International Filing Date: 02.02.2006
IPC:
C07D 417/12 (2006.01), C07D 413/12 (2006.01), A61K 31/4427 (2006.01), A61K 31/497 (2006.01), A61K 31/501 (2006.01), A61K 31/506 (2006.01), A61P 35/00 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London Greater London W1K 1LN (GB) (MG only).
JONES, Clifford, David [GB/GB]; (GB) (For US Only).
LUKE, Richard, William, Arthur [GB/GB]; (GB) (For US Only).
MCCOULL, William [GB/GB]; (GB) (For US Only)
Inventors: JONES, Clifford, David; (GB).
LUKE, Richard, William, Arthur; (GB).
MCCOULL, William; (GB)
Agent: GLOBAL INTELLECTUAL PROPERTY; AstraZeneca AB, S-151 85 Södertälje (SE)
Priority Data:
0502418.7 05.02.2005 GB
Title (EN) COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY
(FR) COMPOSES POSSEDANT UNE ACTIVITE INHIBITRICE DE TIE2 (TEK)
Abstract: front page image
(EN)The invention relates to a compound of the Formula (I) I or salt, prodrug or solvate thereof, wherein R1, R5, R6, D, A, B, L, n, m and p are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm blooded animal. The invention also relates to processes for the preparation of said compounds.
(FR)La présente invention concerne un composé de formule (I) ou un sel, promédicament ou solvate de celui-ci, où R1, R5, R6, D, A, B, L, n, m et p sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques desdits composés, et l'utilisation desdits composés en tant que médicaments et pour la production d'un effet anti-angiogénique chez un animal à sang chaud. L'invention décrit en outre des méthodes de préparation desdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)