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1. (WO2006082010) INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/082010    International Application No.:    PCT/EP2006/000786
Publication Date: 10.08.2006 International Filing Date: 30.01.2006
Chapter 2 Demand Filed:    03.08.2006    
IPC:
C07C 243/36 (2006.01), C07C 243/38 (2006.01), C07C 255/53 (2006.01), C07C 317/22 (2006.01), C07C 321/28 (2006.01), C07D 307/68 (2006.01), C07D 309/08 (2006.01), C07D 333/38 (2006.01), C07D 335/02 (2006.01), A61K 31/165 (2006.01), A61K 31/166 (2006.01), A61K 31/277 (2006.01), A61K 31/341 (2006.01), A61K 31/351 (2006.01), A61K 31/381 (2006.01)
Applicants: F.HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstr. 124, CH-4070 Basel (CH) (For All Designated States Except US).
BOLIN, David, Robert [US/US]; (US) (For US Only).
MICHOUD, Christophe [FR/US]; (US) (For US Only)
Inventors: BOLIN, David, Robert; (US).
MICHOUD, Christophe; (US)
Agent: SALUD, Carlos; Grenzacherstrasse 124, CH-4070 Basel (CH)
Priority Data:
60/650,671 07.02.2005 US
Title (EN) INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
(FR) INHIBITEURS DE LA DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
Abstract: front page image
(EN)Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein R1, R2, R, R3, R4, R5 and X are as defined in the specification and claims. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
(FR)L'invention concerne des composés de formule (I), ainsi que des sels pharmaceutiquement acceptables de ces composés, R1, R2, R2', R3, R4, R5 et X étant tels que définis dans la description et les revendications. Ces composés et les compositions pharmaceutiques contenant ces composés sont utiles pour traiter des maladies telles que l'obésité, le diabète sucré de type II et le syndrome métabolique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)