WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006081659) MEROTERPENOID INHIBITORS OF PHOSPHOINOSITIDE 3 KINASE (PI3K)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/081659    International Application No.:    PCT/CA2006/000131
Publication Date: 10.08.2006 International Filing Date: 01.02.2006
IPC:
C07D 307/93 (2006.01), C07D 493/04 (2006.01), C07D 413/04 (2006.01), A61K 31/343 (2006.01), A61K 31/403 (2006.01), A61K 31/381 (2006.01)
Applicants: THE UNIVERSITY OF BRITISH COLUMBIA [CA/CA]; University-Industry Liaison Office, #103, 6190 Agronomy Road, Vancouver, British Columbia V6T 1Z3 (CA) (For All Designated States Except US).
WYETH [US/US]; Five Giralda Farms, Madison, New Jersey 07940 (US) (For All Designated States Except US).
ANDERSEN, Raymond [CA/CA]; (CA) (For US Only).
HOLLANDER, Irwin [US/US]; (US) (For US Only).
ROLL, Deborah, M. [US/US]; (US) (For US Only).
KIM, Steven, C. [US/US]; (US) (For US Only).
MALLON, Robert, G. [US/US]; (US) (For US Only).
WILLIAMS, David, E. [CA/CA]; (CA) (For US Only).
MARION, Frederic [FR/FR]; (FR) (For US Only)
Inventors: ANDERSEN, Raymond; (CA).
HOLLANDER, Irwin; (US).
ROLL, Deborah, M.; (US).
KIM, Steven, C.; (US).
MALLON, Robert, G.; (US).
WILLIAMS, David, E.; (CA).
MARION, Frederic; (FR)
Agent: SMART & BIGGAR; Box 11560, Vancouver Centre, Suite 2200, 650 West Georgia Street, Vancouver, British Columbia V6B 4NB (CA)
Priority Data:
60/648,427 01.02.2005 US
60/717,267 16.09.2005 US
Title (EN) MEROTERPENOID INHIBITORS OF PHOSPHOINOSITIDE 3 KINASE (PI3K)
(FR) INHIBITEURS MEROTERPENOIDES DE LA PHOSPHOINOSITIDE 3 KINASE (PI3K)
Abstract: front page image
(EN)Compounds with unique liphagane meroterpenoid carbon skeleton are described (structures I, II, III) together with pharmaceutical compositions and their use. A method of inhibiting the activity of phosphoinositide 3 kinase (PBK) is disclosed. In particular, the invention describes a method of inhibiting PBK, wherein the compound is liphagal, desformyl liphagal, desmethyl liphagal or deshydroxy-desformyl liphagal. The methods and uses are directed to treatment of proliferative diseases, in particular those where PBK alpha is involved.
(FR)L'invention concerne des compositions avec un squelette carboné méroterpénoïde à liphagane unique (structures I, II, III) ainsi que des compositions pharmaceutiques et leur utilisation. Il y est décrit un procédé d'inhibition de l'activité de la phosphoinositide 3 kinase (PI3K). En particulier, l'invention décrit un procédé d'inhibition de la PI3 K, où le composé est un liphagal, desformyl liphagal, desméthyl liphagal ou déshydroxy-desformyl liphagal. Les procédés et les utilisations en question sont destinés au traitement de maladies proliférantes, en particulier celles dans lesquelles la P13K alpha est impliquée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)