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1. (WO2006081279) CONTROL OF DRUG RELEASE BY TRANSIENT MODIFICATION OF LOCAL MICROENVIRONMENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/081279 International Application No.: PCT/US2006/002578
Publication Date: 03.08.2006 International Filing Date: 25.01.2006
IPC:
A61K 38/29 (2006.01) ,A61K 9/00 (2006.01) ,A61K 47/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
29
Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
12
Carboxylic acids; Salts or anhydrides thereof
Applicants:
PRESCOTT, James, H. [US/US]; US (UsOnly)
KREIGER, Timothy [US/US]; US (UsOnly)
PROOS, Elizabeth, Rees [US/US]; US (UsOnly)
MICROCHIPS, INC. [US/US]; 6-B Preston Court Bedford, Massachusetts 01730, US (AllExceptUS)
Inventors:
PRESCOTT, James, H.; US
KREIGER, Timothy; US
PROOS, Elizabeth, Rees; US
Agent:
KING, Kevin, W. ; Sutherland Asbill & Brennan LLP 999 Peachtree Street, NE Atlanta, Georgia 30309-3996, US
Priority Data:
60/646,91325.01.2005US
60/760,12918.01.2006US
Title (EN) CONTROL OF DRUG RELEASE BY TRANSIENT MODIFICATION OF LOCAL MICROENVIRONMENTS
(FR) REGULATION DE LA LIBERATION DE MEDICAMENT PAR LA MODIFICATION TRANSITOIRE DE MICROENVIRONNEMENTS LOCAUX
Abstract:
(EN) Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.
(FR) L'invention concerne des procédés, des formulations et des dispositifs destinés à favoriser la libération de médicament par un dispositif médical. Le procédé permet d'augmenter le taux ou la quantité d'une formulation médicamenteuse libérée par un dispositif d'administration de médicament implantable, ledit procédé consistant à utiliser un agent de modification de libération à l'intérieur ou à proximité du dispositif d'administration de médicament implantable de manière à empêcher la gélification, l'agrégation ou la précipitation de la formulation médicamenteuse libérée par le dispositif. La formulation médicamenteuse et l'agent de modification de libération peuvent être stockés conjointement dans au moins un réservoir situé dans le dispositif d'administration de médicament implantable. En variante, l'agent de modification de libération peut être stocké dans un ou plusieurs réservoirs séparément de la formulation médicamenteuse.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)