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1. (WO2006081190) COMPOSITIONS AND METHODS FOR TREATING CARDIAC CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/081190    International Application No.:    PCT/US2006/002313
Publication Date: 03.08.2006 International Filing Date: 25.01.2006
IPC:
A61K 38/18 (2006.01), A61K 38/21 (2006.01), A61P 9/00 (2006.01)
Applicants: FIVE PRIME THERAPEUTICS, INC. [US/US]; 1650 Owens Street, Suite 200, San Francisco, California 94158-2261 (US) (For All Designated States Except US).
WILLIAMS, Lewis, T. [US/US]; (US) (For US Only).
ZHANG, Hongbing [CN/US]; (US) (For US Only).
WANG, Yan [CN/US]; (US) (For US Only).
MASUOKA, Loriane [US/US]; (US) (For US Only).
DOBERSTEIN, Stephen [US/US]; (US) (For US Only)
Inventors: WILLIAMS, Lewis, T.; (US).
ZHANG, Hongbing; (US).
WANG, Yan; (US).
MASUOKA, Loriane; (US).
DOBERSTEIN, Stephen; (US)
Agent: GARRETT, Arthur, S.; FINNEGAN, HENDERSON, FARABOW, GARRETT & DUNNER LLP, 901 New York Avenue, NW, Washington, DC 20001-4413 (US)
Priority Data:
60/646,520 25.01.2005 US
60/675,086 27.04.2005 US
60/675,859 29.04.2005 US
60/701,474 22.07.2005 US
60/716,491 14.09.2005 US
60/739,815 25.11.2005 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING CARDIAC CONDITIONS
(FR) COMPOSITIONS ET METHODES DE TRAITEMENT DE TROUBLES CARDIAQUES
Abstract: front page image
(EN)Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiements, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-betal-HRG-betal, FGF 9.
(FR)L'invention concerne des compositions polypeptidiques pharmaceutiques destinées à promouvoir la survie des cellules cardiaques, à amener des cellules cardiaques dans la zone cardiaque, à stimuler la différenciation des cellules cardiaque, à stimuler la prolifération des cellules cardiaques, et à promouvoir l'activité des cellules cardiaques, traitant ainsi les troubles cardiaques. Ces compositions sont administrées dans la zone cardiaque par cathétérisation et par injection directe.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)