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1. (WO2006081074) CHARGE NEUTRALIZATION OF POLYION COMPLEXES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/081074    International Application No.:    PCT/US2006/001037
Publication Date: 03.08.2006 International Filing Date: 12.01.2006
IPC:
C12N 15/00 (2006.01), C12N 15/09 (2006.01), C12N 15/70 (2006.01), C12N 15/74 (2006.01)
Applicants: MIRUS BIO CORPORATION [US/US]; 505 S. Rosa Rd., Madison, Wisconsin 53719 (US) (For All Designated States Except US).
WAKEFIELD, Darren, H. [US/US]; (US) (For US Only).
ROZEMA, David, B. [US/US]; (US) (For US Only).
WOLFF, Jon, A. [US/US]; (US) (For US Only).
TRUBETSKOY, Vladimir [US/US]; (US) (For US Only).
HAGSTROM, James, E. [US/US]; (US) (For US Only).
BUDKER, Vladimir, G. [US/US]; (US) (For US Only).
KLEIN, Jason [US/US]; (US) (For US Only).
WONG, So [US/US]; (US) (For US Only)
Inventors: WAKEFIELD, Darren, H.; (US).
ROZEMA, David, B.; (US).
WOLFF, Jon, A.; (US).
TRUBETSKOY, Vladimir; (US).
HAGSTROM, James, E.; (US).
BUDKER, Vladimir, G.; (US).
KLEIN, Jason; (US).
WONG, So; (US)
Agent: MIRUS BIO CORPORATION; 505 S. Rosa Rd., Madison, WI 53719 (US)
Priority Data:
60/647,293 26.01.2005 US
11/046,598 28.01.2005 US
Title (EN) CHARGE NEUTRALIZATION OF POLYION COMPLEXES
(FR) NEUTRALISATION DE CHARGE DE COMPLEXES DE POLYIONS
Abstract: front page image
(EN)Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic acid. Stabilized polycation/nucleic acid complexes can be modified to reduce the positive charge of the polycation and add targeting ligands without destabilizing the complex. The resultant particles retain their small size and are more effective in delivery of nucleic acid to cells in vivo.
(FR)L'invention concerne des polyampholytes capables de condenser l'acide nucléique de manière à constituer de petits complexes pouvant être utilisés dans l'apport d'acide nucléique à des cellules de mammifère. Les polyampholytes peuvent être constitués avant l'interaction avec l'acide nucléique ou en présence de l'acide nucléique. Il est possible de modifier des complexes polycation/acide nucléique stabilisés pour réduire la charge positive de polycation et pour ajouter des ligands de ciblage sans déstabiliser le complexe. Les particules obtenues conservent leur petite dimension et sont plus efficaces dans l'apport d'acide nucléique à des cellules in vivo.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)