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1. (WO2006081000) (POLYALKOXY)SULFONATE SURFACE MODIFIERS

Pub. No.:    WO/2006/081000    International Application No.:    PCT/US2005/045321
Publication Date: Aug 3, 2006 International Filing Date: Dec 15, 2005
IPC: C08G 65/326
C08G 65/334
C08L 71/02
Applicants: BAXTER INTERNATIONAL INC.
BAXTER HEALTHCARE S.A.
KIPP, James E.
HAI, Ton That
MELNICK, Bennett, P.
Inventors: KIPP, James E.
HAI, Ton That
MELNICK, Bennett, P.
Title: (POLYALKOXY)SULFONATE SURFACE MODIFIERS
Abstract:
The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.