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1. (WO2006080937) SCREENING ASSAYS FOR ANTIMICROBIAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/080937    International Application No.:    PCT/US2005/014398
Publication Date: 03.08.2006 International Filing Date: 27.04.2005
IPC:
C12Q 1/00 (2006.01), C12Q 1/68 (2006.01), C12Q 1/48 (2006.01), G01N 33/53 (2006.01), G01N 33/557 (2006.01), C12N 15/09 (2006.01), C12N 9/00 (2006.01), C12N 9/12 (2006.01)
Applicants: ACTIVBIOTICS, INC. [US/US]; 128 Spring Street, Lexington, Massachusetts 02421 (US) (For All Designated States Except US).
MURPHY, Christopher K. [US/US]; (US) (For US Only).
ROTHSTEIN, David M. [US/US]; (US) (For US Only).
MACNEIL, Ian [US/US]; (US) (For US Only)
Inventors: MURPHY, Christopher K.; (US).
ROTHSTEIN, David M.; (US).
MACNEIL, Ian; (US)
Agent: ELBING, Karen L., Ph.D.; CLARK & ELBING LLP, 101 Federal Street, Boston, Massachusetts 02110 (US)
Priority Data:
60/565,679 27.04.2004 US
60/566,858 30.04.2004 US
Title (EN) SCREENING ASSAYS FOR ANTIMICROBIAL AGENTS
(FR) DOSAGES DE CRIBLAGE POUR AGENTS ANTIMICROBIENS
Abstract: front page image
(EN)The present invention provides methods for screening antimicrobial agents that make use of mutated microbial polypeptides. Because these polypeptides have biological activity and result in increased antimicrobial drug resistance, candidate compounds that specifically target these polypeptides provide therapeutics or therapeutic lead compounds for treating infections caused by drug resistant microbial pathogens.
(FR)La présente invention a trait à des procédés pour le criblage d'agents antimicrobiens mettant en oeuvre des polypeptides microbiens mutés. Etant donné que ces polypeptides présentent une activité biologique et entraînent une résistance accrue aux médicaments antimicrobiens, des composés candidats de ciblage spécifique desdits polypeptides fournissent des agents thérapeutiques ou des têtes de série thérapeutiques pour le traitement d'infections provoquées par des agents pathogènes microbiens résistants aux médicaments.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)