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1. (WO2006080581) AGENT FOR CONTROL OF DEGRANULATION REACTION AND CYTOKINE PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/080581    International Application No.:    PCT/JP2006/301932
Publication Date: 03.08.2006 International Filing Date: 31.01.2006
IPC:
A61K 45/00 (2006.01), A61K 31/4402 (2006.01), A61P 37/02 (2006.01), A61P 37/08 (2006.01), A61P 43/00 (2006.01), C12Q 1/02 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: RIKEN [JP/JP]; 2-1, Hirosawa, Wako-shi, Saitama 3510198 (JP) (For All Designated States Except US).
HIRANO, Toshio [JP/JP]; (JP) (For US Only).
NISHIDA, Keigo [JP/JP]; (JP) (For US Only)
Inventors: HIRANO, Toshio; (JP).
NISHIDA, Keigo; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg. 1-1, Fushimimachi 4-chome Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2005-023196 31.01.2005 JP
Title (EN) AGENT FOR CONTROL OF DEGRANULATION REACTION AND CYTOKINE PRODUCTION
(FR) AGENT DE REGULATION DE LA REACTION DE DEGRANULATION ET DE LA PRODUCTION DE CYTOKINE
(JA) 脱顆粒反応及びサイトカイン産生の制御剤
Abstract: front page image
(EN)Disclosed is an agent for controlling the degranulation reaction and/or cytokine production in mast cells or the like. A degranulation reaction controlling agent or a cytokine production controlling agent comprising, as an active ingredient, a substance capable of controlling the concentration of zinc ions in a cell, specifically a zinc ion, a zinc ion chelator, a substance capable of controlling the expression and/or function of a zinc ion-requiring protein or a substance capable of controlling the expression and/or function of a zinc ion transporter.
(FR)La présente invention concerne un agent qui permet de réguler la réaction de dégranulation et/ou la production de cytokine dans les mastocytes ou des cellules similaires. L'agent de régulation de la réaction de dégranulation ou l'agent de régulation de la production cytokine comprend en tant que matière active, une substance capable de réguler la concentration des ions zinc dans une cellule. Spécifiquement, cette substance est un ion zinc, un chélateur d'ions zinc, une substance capable de réguler l'expression et/ou la fonction d'une protéine requérant un ion zinc ou une substance capable de réguler l'expression et/ou la fonction d'un transporteur d'ions zinc.
(JA)肥満細胞等の脱顆粒反応及び/又はサイトカイン産生を制御し得る薬剤の提供。細胞内の亜鉛イオン濃度を制御し得る物質、具体的には亜鉛イオン、亜鉛イオンキレーター、亜鉛イオン要求性タンパク質の発現及び/又は機能を調節する物質、あるいは亜鉛イオントランスポーターの発現及び/又は機能を調節する物質を有効成分として含有する脱顆粒反応制御剤並びにサイトカイン産生制御剤。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)