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1. (WO2006080327) ANTICANCER DRUG CONTAINING &agr;,&agr;,&agr;-TRIFLUOROTHYMIDINE AND THYMIDINE PHOSPHORYLASE INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/080327    International Application No.:    PCT/JP2006/301097
Publication Date: 03.08.2006 International Filing Date: 25.01.2006
IPC:
A61K 31/7068 (2006.01), A61K 31/506 (2006.01), A61P 35/00 (2006.01)
Applicants: TAIHO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-27, Kandanishiki-cho, Chiyoda-ku, Tokyo 1018444 (JP) (For All Designated States Except US).
EMURA, Tomohiro [JP/JP]; (JP) (For US Only).
MITA, Akira [JP/JP]; (JP) (For US Only)
Inventors: EMURA, Tomohiro; (JP).
MITA, Akira; (JP)
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Kyodo Bldg., 3-6, Nihonbashiningyocho 1-chome, Chuo-ku, Tokyo 1030013 (JP)
Priority Data:
11/042,059 26.01.2005 US
2005-165156 06.06.2005 JP
Title (EN) ANTICANCER DRUG CONTAINING &agr;,&agr;,&agr;-TRIFLUOROTHYMIDINE AND THYMIDINE PHOSPHORYLASE INHIBITOR
(FR) MÉDICAMENTS ANTICANCÉREUX CONTENANT DE LA &agr;,&agr;,&agr;-TRIFLUOROTHYMIDINE ET UN INHIBITEUR DE LA THYMIDINE PHOSPHORYLASE
(JA) α,α,α-トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤
Abstract: front page image
(EN)A drug for cancer treatment enhanced in efficacy and safety. There is provided a drug for cancer treatment comprised of a composition containing &agr;,&agr;,&agr;-trifluorothymidine (FTD) and 5-chloro-6-(1-(2-iminopyrrolidinyl)methyl)uracil hydrochloride in a molar ratio of 1:0.5. The drug for cancer treatment is orally administered in a dosage of 20 to 80 mg/m2/day in terms of FTD, the dosage divided and given two to four times each day.
(FR)La présente invention décrit un médicament destiné au traitement de cancers et dont l'efficacité et la sûreté d'emploi sont améliorées. La présente invention décrit notamment un médicament destiné au traitement de cancers qui comprend une préparation contenant de la &agr;,&agr;,&agr;-trifluorothymidine (FTD) et du chlorhydrate de 5-chloro-6-(1-(2-iminopyrrolidinyl)méthyl)uracile dans un rapport molaire de 1:0,5. Le médicament destiné au traitement de cancers est administré par voie orale à raison de 20 à 80 mg/m2/jour de FTD, cette dose étant divisée et administrée quotidiennement en deux à quatre fois.
(JA) より有効で安全な癌治療薬の提供。  α,α,α-トリフルオロチミジン(FTD)と5-クロロ-6-(1-(2-イミノピロリジニル)メチル)ウラシル塩酸塩とをモル比1:0.5で含有する組成物であって、FTD換算量として20~80mg/m2/日の用量を1日2~4回に分割して経口投与するための癌治療薬。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)