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1. (WO2006079896) STABLE POLYOL FORMULATIONS OF OXAZOLIDINONE ANTIBACTERIAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/079896    International Application No.:    PCT/IB2006/000117
Publication Date: 03.08.2006 International Filing Date: 17.01.2006
Chapter 2 Demand Filed:    17.03.2006    
IPC:
A61K 47/10 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY LLC [US/US]; 7000 Portage Road, Kalamazoo, MI 49001-0199 (US) (For All Designated States Except US).
PENA, Lorraine, Elisabeth [US/US]; (US) (For US Only).
SECREAST, Pamela, Jean [US/US]; (US) (For US Only)
Inventors: PENA, Lorraine, Elisabeth; (US).
SECREAST, Pamela, Jean; (US)
Agent: FULLER, Grover, F., Jr.; Pfizer Inc., 150 East 42nd Street, New York, NY 10017-5612 (US)
Priority Data:
60/647,561 27.01.2005 US
Title (EN) STABLE POLYOL FORMULATIONS OF OXAZOLIDINONE ANTIBACTERIAL AGENTS
(FR) FORMULATIONS STABLES DE POLYOL D'AGENTS ANTIBACTERIENS A BASE D'OXAZOLIDINONE
Abstract: front page image
(EN)Stable gel formulations of oxazolidinone antibiotic drugs, such as linezolid, are provided which are suitable for topical administration. Gel formulations of the present invention comprise an oxazolidinone antibiotic drug solubilized in a polyol solvent system including a polyol solvent, a thickening agent, and water. The oxazolidinone drug remains solubilized in gel formulations of the present formulation for at least 3 hours at a temperature from 15°C to 30°C. Also provided are methods of topically administering gel formulations of the present invention to treat or prevent infection by gram-positive bacteria.
(FR)La présente invention a trait à des formulations stables en gel de médicaments antibiotiques à base d'oxazolidinone, tel que le linézolide, aptes à une administration topique. Des formulations en gel de la présente invention comporte un médicament antibiotique à base d'oxazolidinone solubilisé dans un système solvant de polyol comprenant un solvant polyol, un agent épaississant, et de l'eau. Le médicament à base d'oxazolidinone reste solubilisé dans des formulations en gel de la formulation de la présente invention pour au moins 3 heures à une température comprise entre 15 °C et 30 °C. L'invention a également trait à des procédés d'administration topique des formulations en gel de la présente invention pour le traitement ou la prévention d'infection par des bactéries gram positif.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)