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1. WO2006079792 - METHODS OF AUTOPHAGY INDUCTION IN MAMMALIAN CELLS

Publication Number WO/2006/079792
Publication Date 03.08.2006
International Application No. PCT/GB2006/000224
International Filing Date 23.01.2006
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61K 31/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61K 31/436
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
436the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/6615
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion ; or mevinphos
6615Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
A61K 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • CAMBRIDGE ENTERPRISE LIMITED [GB]/[GB] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW)
  • RUBINSZTEIN, David [GB]/[GB] (UsOnly)
  • SARKAR, Sovan [IN]/[GB] (UsOnly)
Inventors
  • RUBINSZTEIN, David
  • SARKAR, Sovan
Agents
  • SUTCLIFFE, Nicholas
Priority Data
0501562.325.01.2005GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF AUTOPHAGY INDUCTION IN MAMMALIAN CELLS
(FR) PROCEDES D'INDUCTION D'AUTOPHAGIE DANS DES CELLULES MAMMALIENNES
Abstract
(EN)
Methods of Autophagy Induction in Mammalian Cells. This invention relates to the induction of autophagy in cells through inhibition of inositol monophosphatase (IMPase) and reduction in the level of free inositol (IP3). This may, for example, be useful in the treatment of a range of conditions, including neurodegenerative disorders and bacterial infections such as tuberculosis. Therapeutic compounds, uses and methods of treatment are provided, along with methods of screening for autophagy inducers.
(FR)
La présente invention se rapporte à des procédés d'induction d'autophagie dans des cellules mammaliennes. Cette invention se rapporte à l'induction de l'autophagie dans des cellules par l'intermédiaire de l'inhibition de l'inositol monophosphatase (IMPase) et de la réduction du taux d'inositol libre (IP3). Ceci peut s'avérer utile, par exemple, pour le traitement d'un ensemble de troubles, notamment les troubles neurodégénératifs et les infections bactériennes telles que la tuberculose. L'invention se rapporte également à des composés thérapeutiques, à leurs utilisations et à des méthodes de traitement ainsi qu'à des procédés de criblage d'inducteurs d'autophagie.
Also published as
EP6701109
Latest bibliographic data on file with the International Bureau