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Machine translation
1. (WO2006079205) A METHOD OF CRYOPRESERVING CELLS AND TISSUES BY LIPOSOMAL DELIVERY OF SUGARS TO ENHANCE POST-THAW VIABILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/079205    International Application No.:    PCT/CA2006/000098
Publication Date: 03.08.2006 International Filing Date: 26.01.2006
Chapter 2 Demand Filed:    28.11.2006    
IPC:
C12N 5/02 (2006.01)
Applicants: CANADIAN BLOOD SERVICES [CA/CA]; 1800 Alta Vista Drive, Ottawa, Ontario K1G 4J5 (CA) (For All Designated States Except US).
ACKER, Jason P. [CA/CA]; (CA) (For US Only).
GYONGYOSSY-ISSA, Maria [CA/CA]; (CA) (For US Only)
Inventors: ACKER, Jason P.; (CA).
GYONGYOSSY-ISSA, Maria; (CA)
Agent: OGILVY RENAULT LLP; Suite 1500, 45 O'Connor Street, Ottawa, Ontario K1P 1A4 (CA)
Priority Data:
60/647,403 28.01.2005 US
Title (EN) A METHOD OF CRYOPRESERVING CELLS AND TISSUES BY LIPOSOMAL DELIVERY OF SUGARS TO ENHANCE POST-THAW VIABILITY
(FR) METHODE DE CRYOCONSERVATION DE CELLULES ET DE TISSUS PAR APPORT LIPOSOMAL DE SUCRES AFIN D'AMELIORER LA VIABILITE POST-DECONGELATION
Abstract: front page image
(EN)A method for cryopreserving cells entails the liposomal delivery of intracellular sugar(s), such as trehalose, sucrose, raffinose, stachyose, and combinations thereof, into cells and tissues, such as red blood cells, for enhancing post-thaw viability. This method enables rapid and easy delivery of protective molecules into cells which thus greatly simplifies the preparation of cells for cryopreservation. Furthermore, as much lower concentrations of intracellular protectant are used, the method allows red blood cells containing the liposomally-delivered intracellular sugar to be transfused into a patient immediately following the thaw without having to first remove any of the cryoprotectant sugar.
(FR)L'invention concerne une méthode de cryoconservation de cellules impliquant l'apport liposomal de sucre(s) intracellulaire(s), tel que le tréhalose, le sucrose, le raffinose, la stachyose et des combinaisons de ces derniers, dans des cellules et des tissus, tels que des globules rouges, afin d'améliorer la viabilité post-décongélation. Ladite méthode permet l'apport rapide et aisé de molécules protectrices dans des cellules, ce qui simplifie ainsi considérablement la préparation de cellules pour la cryoconservation. De plus, étant donné que des concentrations beaucoup plus faibles de protecteur intracellulaire sont utilisées, la méthode permet la transfusion des globules rouges contenant le sucre intracellulaire apporté par voie liposomale à un patient immédiatement après la décongélation sans avoir à tout d'abord éliminer un quelconque sucre cryoprotecteur.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)