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1. (WO2006077501) DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/077501 International Application No.: PCT/IB2006/001097
Publication Date: 27.07.2006 International Filing Date: 13.01.2006
IPC:
C07H 17/08 (2006.01) ,A61K 31/7048 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
08
Hetero rings containing eight or more ring members, e.g. erythromycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
Applicants:
CULIC, Ognjen [HR/HR]; HR (UsOnly)
BOSNAR, Martina [HR/HR]; HR (UsOnly)
ALIHODZIC, Sulejman [HR/HR]; HR (UsOnly)
LAZAREVSKI, Gorjana [HR/HR]; HR (UsOnly)
ISTUK MARUSIC, Zorica [HR/HR]; HR (UsOnly)
HUTINEC, Antun [HR/HR]; HR (UsOnly)
VELA, Vanja [HR/HR]; HR (UsOnly)
KRAGOL, Goran [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz Baruna Filipovica 29 10000 Zagreb, HR (AllExceptUS)
Inventors:
CULIC, Ognjen; HR
BOSNAR, Martina; HR
ALIHODZIC, Sulejman; HR
LAZAREVSKI, Gorjana; HR
ISTUK MARUSIC, Zorica; HR
HUTINEC, Antun; HR
VELA, Vanja; HR
KRAGOL, Goran; HR
Agent:
CRAWLEY, Karen; GlaxoSmithKline Corporate Intellectual Property 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
60/643,84013.01.2005US
Title (EN) DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
(FR) DECLADINOSYL-MACROLIDES PRESENTANT UNE ACTIVITE ANTI-INFLAMMATOIRE
Abstract:
(EN) The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-&agr;, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
(FR) La présente invention concerne des nouveaux macrolides semi-synthétiques présentant une activité anti-inflammatoire. Plus particulièrement, cette invention concerne des macrolides à 14 et 15 ramifications sans sucre de cladinose substitué à la position C-3, des dérivés pharmaceutiquement acceptables, des procédés et des produits intermédiaires permettant leur préparation, des compositions pharmaceutiques les contenant ainsi que leur activité et leur utilisation dans le traitement de maladies et affections inflammatoires chez des humains et des animaux, plus spécialement, des maladies associées à une sécrétion excessive de TNF-a, IL-1, IL-6, IL-8, IL-2 ou de IL-5; et/ou un inhibiteur de la prolifération excessive des lymphocites; et/ou de dégranulation excessive des granulocytes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)