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1. WO2006077501 - DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY

Publication Number WO/2006/077501
Publication Date 27.07.2006
International Application No. PCT/IB2006/001097
International Filing Date 13.01.2006
IPC
C07H 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
A61K 31/7048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
04Antipruritics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR]/[HR] (AllExceptUS)
  • CULIC, Ognjen [HR]/[HR] (UsOnly)
  • BOSNAR, Martina [HR]/[HR] (UsOnly)
  • ALIHODZIC, Sulejman [HR]/[HR] (UsOnly)
  • LAZAREVSKI, Gorjana [HR]/[HR] (UsOnly)
  • ISTUK MARUSIC, Zorica [HR]/[HR] (UsOnly)
  • HUTINEC, Antun [HR]/[HR] (UsOnly)
  • VELA, Vanja [HR]/[HR] (UsOnly)
  • KRAGOL, Goran [HR]/[HR] (UsOnly)
Inventors
  • CULIC, Ognjen
  • BOSNAR, Martina
  • ALIHODZIC, Sulejman
  • LAZAREVSKI, Gorjana
  • ISTUK MARUSIC, Zorica
  • HUTINEC, Antun
  • VELA, Vanja
  • KRAGOL, Goran
Agents
  • CRAWLEY, Karen
Priority Data
60/643,84013.01.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
(FR) DECLADINOSYL-MACROLIDES PRESENTANT UNE ACTIVITE ANTI-INFLAMMATOIRE
Abstract
(EN) The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-&agr;, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
(FR) La présente invention concerne des nouveaux macrolides semi-synthétiques présentant une activité anti-inflammatoire. Plus particulièrement, cette invention concerne des macrolides à 14 et 15 ramifications sans sucre de cladinose substitué à la position C-3, des dérivés pharmaceutiquement acceptables, des procédés et des produits intermédiaires permettant leur préparation, des compositions pharmaceutiques les contenant ainsi que leur activité et leur utilisation dans le traitement de maladies et affections inflammatoires chez des humains et des animaux, plus spécialement, des maladies associées à une sécrétion excessive de TNF-a, IL-1, IL-6, IL-8, IL-2 ou de IL-5; et/ou un inhibiteur de la prolifération excessive des lymphocites; et/ou de dégranulation excessive des granulocytes.
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