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1. (WO2006077501) DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY

Pub. No.:    WO/2006/077501    International Application No.:    PCT/IB2006/001097
Publication Date: Fri Jul 28 01:59:59 CEST 2006 International Filing Date: Sat Jan 14 00:59:59 CET 2006
IPC: C07H 17/08
A61K 31/7048
Applicants: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.
CULIC, Ognjen
BOSNAR, Martina
ALIHODZIC, Sulejman
LAZAREVSKI, Gorjana
ISTUK MARUSIC, Zorica
HUTINEC, Antun
VELA, Vanja
KRAGOL, Goran
Inventors: CULIC, Ognjen
BOSNAR, Martina
ALIHODZIC, Sulejman
LAZAREVSKI, Gorjana
ISTUK MARUSIC, Zorica
HUTINEC, Antun
VELA, Vanja
KRAGOL, Goran
Title: DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
Abstract:
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.