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1. WO2006067437 - OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS

Publication Number WO/2006/067437
Publication Date 29.06.2006
International Application No. PCT/GB2005/004969
International Filing Date 21.12.2005
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Benzo [b] furans; Hydrogenated benzo [b] furans
82
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
84
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343
condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C07D 307/84 (2006.01)
A61K 31/343 (2006.01)
A61P 25/00 (2006.01)
CPC
C07D 307/84
C07D 317/48
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
  • BOZZOLI, Andrea [IT/IT]; IT (UsOnly)
  • BRANCH, Clive, Leslie [GB/GB]; GB (UsOnly)
  • MACRITCHIE, Jacqueline, Anne [GB/GB]; GB (UsOnly)
  • MARSHALL, Howard, Robert [GB/GB]; GB (UsOnly)
  • PORTER, Roderick, Alan [GB/GB]; GB (UsOnly)
  • SPADA, Simone [IT/IT]; IT (UsOnly)
Inventors
  • BOZZOLI, Andrea; IT
  • BRANCH, Clive, Leslie; GB
  • MACRITCHIE, Jacqueline, Anne; GB
  • MARSHALL, Howard, Robert; GB
  • PORTER, Roderick, Alan; GB
  • SPADA, Simone; IT
Agents
  • CONNELL, Anthony, Christopher; GlaxoSmithKline Corporate Intellectual Property (cn925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data
0428232.323.12.2004GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS
(FR) HÉTÉROCYCLES OXYGÉNÉS EN TANT QUE COMPOSÉS INHIBITEURS DE TRANSPORTEURS DE GLYCINE
Abstract
(EN)
The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R1 is a group selected from:
(FR)
La présente invention concerne des composés de formule (I), ou des sels ou solvates desdits composés, ainsi que leur emploi dans la fabrication de médicaments destinés au traitement de troubles neurologiques et neuropsychiatriques, en particulier les troubles tels que les psychoses, la démence ou le déficit d'attention. La présente invention décrit en outre des procédés permettant d'élaborer ces composés ainsi que les formules pharmaceutiques correspondantes. Dans ladite formule (I), R1 est un groupement sélectionné parmi A, B et C.
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