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1. (WO2006067430) 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/067430 International Application No.: PCT/GB2005/004960
Publication Date: 29.06.2006 International Filing Date: 21.12.2005
IPC:
C07D 215/48 (2006.01) ,C07C 233/80 (2006.01) ,A61K 31/166 (2006.01) ,A61K 31/47 (2006.01) ,C07D 215/50 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
80
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
50
attached in position 4
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
BOZZOLI, Andrea [IT/IT]; IT (UsOnly)
BRANCH, Clive Leslie [GB/GB]; GB (UsOnly)
MACRITCHIE, Jacqueline, Anne [GB/GB]; GB (UsOnly)
MARSHALL, Howard, Robert [GB/GB]; GB (UsOnly)
PORTER, Roderick, Alan [GB/GB]; GB (UsOnly)
SPADA, Simone [IT/IT]; IT (UsOnly)
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
Inventors:
BOZZOLI, Andrea; IT
BRANCH, Clive Leslie; GB
MACRITCHIE, Jacqueline, Anne; GB
MARSHALL, Howard, Robert; GB
PORTER, Roderick, Alan; GB
SPADA, Simone; IT
Agent:
CONNELL, Anthony, Christopher; GlaxoSmithKline Corporate Intellectual Property (CN925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
0428233.123.12.2004GB
Title (EN) 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES
(FR) DÉRIVÉS DE 2-AMINO-1-PHÉNYLÉTHYLCARBOXAMIDE
Abstract:
(EN) The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R1 is a group selected from: Formulas (A), (B), (C)
(FR) La présente invention concerne des composés de formule (I), ou des sels ou solvates desdits composés, ainsi que leur emploi dans la fabrication de médicaments destinés au traitement de troubles neurologiques et neuropsychiatriques, en particulier les troubles tels que les psychoses, la démence ou le déficit d'attention. La présente invention décrit en outre des procédés permettant d'élaborer ces composés ainsi que les formules pharmaceutiques correspondantes. Formule (I) où R1 est un groupement sélectionné parmi : Formules (A), (B), (C)
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)