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1. WO2006067423 - GLYCINE TRANSPORT INHIBITORS

Publication Number WO/2006/067423
Publication Date 29.06.2006
International Application No. PCT/GB2005/004951
International Filing Date 21.12.2005
Chapter 2 Demand Filed 01.08.2006
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
33
having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34
of a saturated carbon skeleton
36
containing at least two amino groups bound to the carbon skeleton
C07C 233/78 (2006.01)
A61K 31/166 (2006.01)
C07C 211/36 (2006.01)
CPC
C07C 233/78
C07C 235/50
C07C 235/60
C07C 2601/02
C07C 2601/08
C07C 2601/14
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
  • BRADLEY, Daniel, Marcus [GB/GB]; GB (UsOnly)
  • BRANCH, Clive, Leslie [GB/GB]; GB (UsOnly)
  • CHAN, Wai, Ngor [GB/GB]; GB (UsOnly)
  • COULTON, Steven [GB/GB]; GB (UsOnly)
  • GILPIN, Martin, Leonard [GB/GB]; GB (UsOnly)
  • HARRIS, Andrew, Jonathan [GB/GB]; GB (UsOnly)
  • JAXA-CHAMIEC, Albert, Andrzej [GB/GB]; GB (UsOnly)
  • LAI, Justine, Yeun, Quai [SG/GB]; GB (UsOnly)
  • MARSHALL, Howard, Robert [GB/GB]; GB (UsOnly)
  • MACRITCHIE, Jacqueline, Anne [GB/GB]; GB (UsOnly)
  • NASH, David, John [GB/GB]; GB (UsOnly)
  • PORTER, Roderick, Alan [GB/GB]; GB (UsOnly)
  • SPADA, Simone [IT/IT]; IT (UsOnly)
  • THEWLIS, Kevin, Michael [GB/GB]; GB (UsOnly)
  • WARD, Simon, Edward [GB/GB]; GB (UsOnly)
Inventors
  • BRADLEY, Daniel, Marcus; GB
  • BRANCH, Clive, Leslie; GB
  • CHAN, Wai, Ngor; GB
  • COULTON, Steven; GB
  • GILPIN, Martin, Leonard; GB
  • HARRIS, Andrew, Jonathan; GB
  • JAXA-CHAMIEC, Albert, Andrzej; GB
  • LAI, Justine, Yeun, Quai; GB
  • MARSHALL, Howard, Robert; GB
  • MACRITCHIE, Jacqueline, Anne; GB
  • NASH, David, John; GB
  • PORTER, Roderick, Alan; GB
  • SPADA, Simone; IT
  • THEWLIS, Kevin, Michael; GB
  • WARD, Simon, Edward; GB
Agents
  • CONNELL, Anthony, Christopher; GlaxoSmithKline Corporate Intellectual Property (CN925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data
0428231.523.12.2004GB
0509204.405.05.2005GB
0524320.929.11.2005GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GLYCINE TRANSPORT INHIBITORS
(FR) INHIBITEURS DE TRANSPORT DE LA GLYCINE
Abstract
(EN)
The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
(FR)
La présente invention concerne des composés de formule (I), ou des sels ou solvates desdits composés, ainsi que leur emploi dans la fabrication de médicaments destinés au traitement de troubles neurologiques et neuropsychiatriques, en particulier les troubles tels que les psychoses, la démence ou le déficit d'attention. La présente invention décrit en outre des procédés permettant d'élaborer ces composés ainsi que les formules pharmaceutiques correspondantes.
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