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1. (WO2006067417) GLYCINE TRANSPORT INHIBITORS
Latest bibliographic data on file with the International Bureau   
Pub. No.: WO/2006/067417 International Application No.: PCT/GB2005/004943
Publication Date: 29.06.2006 International Filing Date: 21.12.2005
Chapter 2 Demand Filed: 09.08.2006
IPC:
C07C 233/78 (2006.01) ,A61K 31/166 (2006.01) ,C07C 211/27 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
26
of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
27
having amino groups linked to the six-membered aromatic ring by saturated carbon chains
Applicants:
BRADLEY, Daniel, Marcus [GB/GB]; GB (UsOnly)
BRANCH, Clive, Leslie [GB/GB]; GB (UsOnly)
CHAN, Wai, Ngor [GB/GB]; GB (UsOnly)
COULTON, Steven [GB/GB]; GB (UsOnly)
GILPIN, Martin, Leonard [GB/GB]; GB (UsOnly)
HARRIS, Andrew, Jonathan [GB/GB]; GB (UsOnly)
LAI, Justine, Yeun, Quai [SG/GB]; GB (UsOnly)
MARSHALL, Howard, Robert [GB/GB]; GB (UsOnly)
MACRITCHIE, Jacqueline, Anne [GB/GB]; GB (UsOnly)
NASH, David, John [GB/GB]; GB (UsOnly)
PORTER, Roderick, Alan [GB/GB]; GB (UsOnly)
SPADA, Simone [IT/IT]; IT (UsOnly)
THEWLIS, Kevin, Michael [GB/GB]; GB (UsOnly)
WARD, Simon, Edward [GB/GB]; GB (UsOnly)
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
Inventors:
BRADLEY, Daniel, Marcus; GB
BRANCH, Clive, Leslie; GB
CHAN, Wai, Ngor; GB
COULTON, Steven; GB
GILPIN, Martin, Leonard; GB
HARRIS, Andrew, Jonathan; GB
LAI, Justine, Yeun, Quai; GB
MARSHALL, Howard, Robert; GB
MACRITCHIE, Jacqueline, Anne; GB
NASH, David, John; GB
PORTER, Roderick, Alan; GB
SPADA, Simone; IT
THEWLIS, Kevin, Michael; GB
WARD, Simon, Edward; GB
Agent:
CONNELL, Anthony, Christopher; GlaxoSmithKline Corporate Intellectual Property (cn925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
KONDO, Rie; Glaxosmithkline, CIP (CN925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
0428231.523.12.2004GB
0509204.405.05.2005GB
0524322.529.11.2005GB
Title (EN) GLYCINE TRANSPORT INHIBITORS
(FR) INHIBITEURS DU TRANSPORT DE LA GLYCINE
Abstract:
(EN) The present invention relates to compounds of Formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
(FR) La présente invention concerne des composés de Formule (I), ou leurs sels ou solvates, leur utilisation dans la fabrication de médicaments pour traiter des troubles neurologiques et neuropsychiatriques, en particulier les psychoses, la démence ou le trouble déficitaire de l’attention. La présente invention comprend en outre des procédésde production de ces composés et de leurs formulations pharmaceutiques.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)