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1. WO2006067417 - GLYCINE TRANSPORT INHIBITORS

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Publication Number WO/2006/067417
Publication Date 29.06.2006
International Application No. PCT/GB2005/004943
International Filing Date 21.12.2005
Chapter 2 Demand Filed 09.08.2006
IPC
C07C 233/78 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
A61K 31/166 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
166having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
C07C 211/27 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
01having amino groups bound to acyclic carbon atoms
26of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
27having amino groups linked to the six-membered aromatic ring by saturated carbon chains
CPC
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 15/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
10for impotence
A61P 15/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
12for climacteric disorders
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • BRADLEY, Daniel, Marcus [GB]/[GB] (UsOnly)
  • BRANCH, Clive, Leslie [GB]/[GB] (UsOnly)
  • CHAN, Wai, Ngor [GB]/[GB] (UsOnly)
  • COULTON, Steven [GB]/[GB] (UsOnly)
  • GILPIN, Martin, Leonard [GB]/[GB] (UsOnly)
  • HARRIS, Andrew, Jonathan [GB]/[GB] (UsOnly)
  • LAI, Justine, Yeun, Quai [SG]/[GB] (UsOnly)
  • MARSHALL, Howard, Robert [GB]/[GB] (UsOnly)
  • MACRITCHIE, Jacqueline, Anne [GB]/[GB] (UsOnly)
  • NASH, David, John [GB]/[GB] (UsOnly)
  • PORTER, Roderick, Alan [GB]/[GB] (UsOnly)
  • SPADA, Simone [IT]/[IT] (UsOnly)
  • THEWLIS, Kevin, Michael [GB]/[GB] (UsOnly)
  • WARD, Simon, Edward [GB]/[GB] (UsOnly)
Inventors
  • BRADLEY, Daniel, Marcus
  • BRANCH, Clive, Leslie
  • CHAN, Wai, Ngor
  • COULTON, Steven
  • GILPIN, Martin, Leonard
  • HARRIS, Andrew, Jonathan
  • LAI, Justine, Yeun, Quai
  • MARSHALL, Howard, Robert
  • MACRITCHIE, Jacqueline, Anne
  • NASH, David, John
  • PORTER, Roderick, Alan
  • SPADA, Simone
  • THEWLIS, Kevin, Michael
  • WARD, Simon, Edward
Agents
  • CONNELL, Anthony, Christopher
  • KONDO, Rie
Priority Data
0428231.523.12.2004GB
0509204.405.05.2005GB
0524322.529.11.2005GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GLYCINE TRANSPORT INHIBITORS
(FR) INHIBITEURS DU TRANSPORT DE LA GLYCINE
front page image
Abstract
(EN) The present invention relates to compounds of Formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
(FR) La présente invention concerne des composés de Formule (I), ou leurs sels ou solvates, leur utilisation dans la fabrication de médicaments pour traiter des troubles neurologiques et neuropsychiatriques, en particulier les psychoses, la démence ou le trouble déficitaire de l’attention. La présente invention comprend en outre des procédésde production de ces composés et de leurs formulations pharmaceutiques.
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